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MedKoo Cat#: 559003 | Name: Lergotrile mesylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lergotrile mesylate is an ergoline derivative that inhibits prolactin in vivo and in vitro.

Chemical Structure

Lergotrile mesylate
Lergotrile mesylate
CAS#51473-23-5

Theoretical Analysis

MedKoo Cat#: 559003

Name: Lergotrile mesylate

CAS#: 51473-23-5

Chemical Formula: C18H22ClN3O3S

Exact Mass:

Molecular Weight: 395.90

Elemental Analysis: C, 54.61; H, 5.60; Cl, 8.95; N, 10.61; O, 12.12; S, 8.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Lergotrile mesylate; LY 83636; LY-83636; LY83636; 83636;
IUPAC/Chemical Name
2-((6aR,9S,10aR)-5-chloro-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)acetonitrile methanesulfonate
InChi Key
WXHDJVDIJQDJMK-AYJWUPBJSA-N
InChi Code
InChI=1S/C17H18ClN3.CH4O3S/c1-21-9-10(5-6-19)7-12-11-3-2-4-14-16(11)13(8-15(12)21)17(18)20-14;1-5(2,3)4/h2-4,10,12,15,20H,5,7-9H2,1H3;1H3,(H,2,3,4)/t10-,12-,15-;/m1./s1
SMILES Code
[H][C@@]1(N(C)C[C@H](CC#N)C[C@@]12[H])CC3=C(Cl)NC4=C3C2=CC=C4.CS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 395.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sherman BM, Swanson JA, Chapler FK. The treatment of hyperprolactinemia with a new ergot derivative, lergotrile mesylate. Fertil Steril. 1978 Mar;29(3):291-5. PubMed PMID: 565303. 2: Clemens JA, Smalstig EB, Shaar CJ. Inhibition of prolactin secretion by lergotrile mesylate: mechanism of action. Acta Endocrinol (Copenh). 1975 Jun;79(2):230-7. PubMed PMID: 166535. 3: Schmidt MJ. Dopamine agonist-induced hyperglycemia in rats: effects of lergotrile mesylate. Eur J Pharmacol. 1979 Oct 26;59(1-2):95-101. PubMed PMID: 41730. 4: Lieberman A, Estey E, Kupersmith M, Gopinathan G, Goldstein M. Treatment of Parkinson's disease with lergotrile mesylate. JAMA. 1977 Nov 28;238(22):2380-2. PubMed PMID: 335094. 5: Fuller RW, Perry KW. Effect of lergotrile on 3,4-dihydroxyphenylacetic acid (DOPAC) concentration and dopamine turnover in rat brain. J Neural Transm. 1978;42(1):23-35. PubMed PMID: 641542. 6: Thorner MO, Ryan SM, Wass JA, Jones A, Bouloux P, Williams S, Besser GM. Effect of the dopamine agonist, lergotrile mesylate, on circulating anterior pituitary hormones in man. J Clin Endocrinol Metab. 1978 Aug;47(2):372-8. PubMed PMID: 45463. 7: Hooley RD, Fell LR, Findlay JK. The effect of 2-bromo-alpha-ergocryptine and 2-chloro-alpha-methylergoline-8beta-acetonitrile (lergotrile mesylate) on the prolactin secretion of the ewe. Acta Endocrinol (Copenh). 1977 Dec;86(4):722-7. PubMed PMID: 411304. 8: Sinha YN, Salocks CB, VanderLaan WP. A comparison of the effects of CB-154 and lergotrile mesylate on prolactin and growth hormone secretion in mice. Horm Metab Res. 1976 Sep;8(5):332-6. PubMed PMID: 989755. 9: Sved AF, Fernstrom JD. Reduction in blood pressure in normal and spontaneously hypertensive rats by lergotrile mesylate. J Pharm Pharmacol. 1979 Dec;31(12):814-7. PubMed PMID: 43364. 10: Wiggins C, Wise PM, Ratner A. Differences in the response pattern of aged female rats to treatment with lergotrile mesylate. Proc Soc Exp Biol Med. 1985 Jun;179(2):173-9. PubMed PMID: 2859599. 11: Lieberman A, Miyamoto T, Battista AF, Goldstein M. Studies on the antiparkinsonism efficacy of lergotrile. Neurology. 1975 May;25(5):459-62. PubMed PMID: 166332. 12: Klawans HL, Goetz CG, Volkman P, Nausieda PA, Weiner WJ. Lergotrile in the treatment of parkinsonism. Neurology. 1978 Jul;28(7):699-702. PubMed PMID: 566868. 13: Rabinowitz D, McKenna TJ, Benveniste R. Pituitary and adrenal function in normal women after treatment with Lergotrile mesylate. Isr J Med Sci. 1978 Feb;14(2):256-60. PubMed PMID: 418023. 14: Ratner A, Woo W, Yelvington D, Torres K. Effect of lergotrile mesylate and methysergide on morphine induced increase in prolactin release. Proc West Pharmacol Soc. 1981;24:335-9. PubMed PMID: 6114495. 15: Yelvington DB, Weiss GK, Ratner A. Avoidance behavior and plasma prolactin levels in lergotrile mesylate treated rats. Pharmacol Biochem Behav. 1986 Jan;24(1):67-70. PubMed PMID: 2868466. 16: Kleinberg DL, Schaaf M, Frantz AG. Studies with lergotrile mesylate in acromegaly. Fed Proc. 1978 Jun;37(8):2198-201. PubMed PMID: 658458. 17: Kebabian JW, Calne DB, Kebabian PR. Lergotrile mesylate: an in vivo dopamine agonist which blocks dopamine receptors in vitro. Commun Psychopharmacol. 1977;1(4):311-8. PubMed PMID: 615694. 18: Teychenne PF, Jones EA, Ishak KG, Calne DB. Hepatocellular injury with distinctive mitochondrial changes induced by lergotrile mesylate: a dopaminergic ergot derivative. Gastroenterology. 1979 Mar;76(3):575-83. PubMed PMID: 34555. 19: Walters JR, Lakoski JM, Baring MD, Eng N. Dopamine neurons: effect of lergotrile on unit activity and transmitter synthesis. Eur J Pharmacol. 1979 Dec 7;60(2-3):199-210. PubMed PMID: 43259. 20: Leebaw W, Lee L, Woolf P. The effects of the dopamine agonist, lergotrile mesylate, on prolactin secretion in women. Acta Endocrinol (Copenh). 1978 Jan;87(1):12-8. PubMed PMID: 579527.

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