LCL-521 is an inhibitor of acid ceramidase. It inhibits acid ceramidase activity in MCF-7 breast cancer cell lysates when used at a concentration of 1 µM. LCL-521 (1 and 10 µM) decreases sphingosine levels in MCF-7 cells. It inhibits the proliferation of MCF-7 cells (IC50 = 7.46 µM) and induces cell cycle arrest at the G1 phase when used at a concentration of 2.5 µM.
MedKoo Cat#: 465294
Name: LCL-521
CAS#: 1226851-11-1 (free base)
Chemical Formula: C31H52N4O7
Exact Mass: 592.3836
Molecular Weight: 592.78
Elemental Analysis: C, 62.81; H, 8.84; N, 9.45; O, 18.89
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 150.0 | 253.05 | |
| Ethanol | 100.0 | 168.70 |
The following data is based on the product molecular weight 592.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
