Synonym
Oteracil; Oxonic acid
IUPAC/Chemical Name
1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-
InChi Key
RYYCJUAHISIHTL-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H3N3O4/c8-2(9)1-5-3(10)7-4(11)6-1/h(H,8,9)(H2,5,6,7,10,11)
SMILES Code
O=C(C(NC1=O)=NC(N1)=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
157.09
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Matt P, van Zwieten-Boot B, Calvo Rojas G, Ter Hofstede H, Garcia-Carbonero R, Camarero J, Abadie E, Pignatti F. The European Medicines Agency review of Tegafur/Gimeracil/Oteracil (Teysuno™) for the treatment of advanced gastric cancer when given in combination with cisplatin: summary of the Scientific Assessment of the Committee for medicinal products for human use (CHMP). Oncologist. 2011;16(10):1451-7. doi: 10.1634/theoncologist.2011-0224. Epub 2011 Sep 30. PMID: 21963999; PMCID: PMC3228070.
2: Wang J, Wu DX, Meng L, Ji G. Anlotinib combined with SOX regimen (S1 (tegafur, gimeracil and oteracil porassium capsules) + oxaliplatin) in treating stage IV gastric cancer: study protocol for a single-armed and single-centred clinical trial. BMJ Open. 2020 Jun 3;10(6):e034685. doi: 10.1136/bmjopen-2019-034685. PMID: 32499264; PMCID: PMC7279648.
3: Park YJ, Soh BW, Lee ES. Acral lentiginosis associated with tegafur/gimeracil/oteracil (TS-1). Eur J Dermatol. 2017 Apr 1;27(2):209-210. doi: 10.1684/ejd.2016.2953. PMID: 28251899.
4: Liu J, Wang C, Cao L, Li S. Treatment of advanced intrahepatic cholangiocarcinoma with sintilimab combined with tegafur-gimeracil-oteracil potassium capsules (S-1): a case report. Ann Palliat Med. 2020 Mar;9(2):497-503. doi: 10.21037/apm.2020.03.14. Epub 2020 Mar 19. PMID: 32233637.
5: Kim J, Kim SH, Lee MG, Chung KY, Kim DS. Eccrine squamous syringometaplasia of underlying syringoma associated with Tegafur/Gimeracil/Oteracil (TS-1). Acta Derm Venereol. 2015 Nov;95(8):999-1000. doi: 10.2340/00015555-2092. PMID: 25766447.
6: Wang HF, Lv JQ. The Clinical Evaluation of Tegafur Gimeracil Oteracil Combined with THP and DDP for Second-Line Treatment of Advanced Cardiac Carcinoma. Cell Biochem Biophys. 2015 Jul;72(3):695-9. doi: 10.1007/s12013-015-0520-0. PMID: 25618173.
7: Tegafur + gimeracil + oteracil. Just another fluorouracil precursor. Prescrire Int. 2013 May;22(138):122. PMID: 23819172.
8: Ishizuna K, Ninomiya J, Ogawa T, Kojima M, Tsuji E, Kawashima M, Nozaki M, Yamagishi H, Ueda Y. Effectiveness and safety of tegafur-gimeracil-oteracil potassium (TS-1) for metastatic breast cancer: a single-center retrospective study. Gan To Kagaku Ryoho. 2014 Dec;41(13):2577-82. PMID: 25596051.
9: Tsuda A, Fujiyama J, Miki A, Hori S, Ohtani H, Sawada Y. The first case of phenytoin intoxication associated with the concomitant use of phenytoin and TS-1, a combination preparation of tegafur, gimeracil, and oteracil potassium. Cancer Chemother Pharmacol. 2008 Aug;62(3):427-32. doi: 10.1007/s00280-007-0621-6. Epub 2007 Nov 17. PMID: 18026730.
10: Li F, Ju Y, Guan Y, Zhao H. [Tegafur gimeracil oteracil potassium capsule induced acute interstitial lung disease: a case report]. Zhongguo Fei Ai Za Zhi. 2014 Jan;17(1):53-6. Chinese. doi: 10.3779/j.issn.1009-3419.2014.01.09. PMID: 24398315; PMCID: PMC6000209.
