Spermidine-d6 | CAS#2514812-10-1 | Spermidine internal standard

MedKoo Cat#: 465279 | Name: Spermidine-d6

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE). It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.4 Formulations containing spermidine have been used as dietary supplements.

Chemical Structure

Spermidine-d6

CAS#2514812-10-1

Theoretical Analysis

MedKoo Cat#: 465279

Name: Spermidine-d6

CAS#: 2514812-10-1

Chemical Formula: C7H13D6N3

Exact Mass: 151.1956

Molecular Weight: 151.29

Elemental Analysis: C, 55.57; H, 16.65; N, 27.78

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 450.00	2 Weeks
5mg	USD 1,100.00	2 Weeks

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Related CAS #

No Data

Synonym

Spermidine-d6; Spermidine d6;

IUPAC/Chemical Name

N1-(3-aminopropyl-1,1,2,2,3,3-d6)butane-1,4-diamine

InChi Key

ATHGHQPFGPMSJY-RCKJUGKUSA-N

InChi Code

InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2/i3D2,5D2,7D2

SMILES Code

NCCCCNC(C(C(N)([2H])[2H])([2H])[2H])([2H])[2H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM	comments
Solubility
	Water	50.0	330.47

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 151.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Choksomngam Y, Pattanakuhar S, Chattipakorn N, Chattipakorn SC. The metabolic role of spermidine in obesity: Evidence from cells to community. Obes Res Clin Pract. 2021 Jul-Aug;15(4):315-326. doi: 10.1016/j.orcp.2021.06.009. Epub 2021 Jul 1. PMID: 34217652. 2: Sagar NA, Tarafdar S, Agarwal S, Tarafdar A, Sharma S. Polyamines: Functions, Metabolism, and Role in Human Disease Management. Med Sci (Basel). 2021 Jun 9;9(2):44. doi: 10.3390/medsci9020044. PMID: 34207607; PMCID: PMC8293435. 3: Gerlin L, Baroukh C, Genin S. Polyamines: double agents in disease and plant immunity. Trends Plant Sci. 2021 Jun 11:S1360-1385(21)00140-0. doi: 10.1016/j.tplants.2021.05.007. Epub ahead of print. PMID: 34127368. 4: McNamara KM, Gobert AP, Wilson KT. The role of polyamines in gastric cancer. Oncogene. 2021 Jul;40(26):4399-4412. doi: 10.1038/s41388-021-01862-x. Epub 2021 Jun 9. PMID: 34108618; PMCID: PMC8262120. 5: Peng Q, Wong CY, Cheuk IW, Teoh JY, Chiu PK, Ng CF. The Emerging Clinical Role of Spermine in Prostate Cancer. Int J Mol Sci. 2021 Apr 22;22(9):4382. doi: 10.3390/ijms22094382. PMID: 33922247; PMCID: PMC8122740. 6: Ploskonos MV. Polyamines of biological fluids of the body and the diagnostic value of their determination in clinical and laboratory researches (review of literature). Klin Lab Diagn. 2021 Apr 17;66(4):197-204. English. doi: 10.51620/0869-2084-2021-66-4-197-204. PMID: 33878239. 7: Nanduri B, Swiatlo E. The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae. Pneumonia (Nathan). 2021 Mar 25;13(1):4. doi: 10.1186/s41479-021-00082-x. PMID: 33762024; PMCID: PMC7990898. 8: Szeliga M, Albrecht J. Roles of nitric oxide and polyamines in brain tumor growth. Adv Med Sci. 2021 Mar;66(1):199-205. doi: 10.1016/j.advms.2021.02.006. Epub 2021 Mar 9. PMID: 33711670. 9: Gao F, Mei X, Li Y, Guo J, Shen Y. Update on the Roles of Polyamines in Fleshy Fruit Ripening, Senescence, and Quality. Front Plant Sci. 2021 Feb 10;12:610313. doi: 10.3389/fpls.2021.610313. PMID: 33664757; PMCID: PMC7922164. 10: Kitada M, Ogura Y, Monno I, Xu J, Koya D. Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress. Biomedicines. 2021 Jan 29;9(2):130. doi: 10.3390/biomedicines9020130. PMID: 33572965; PMCID: PMC7911310. 11: Tulluri V, Nemmara VV. Role of Antizyme Inhibitor Proteins in Cancers and Beyond. Onco Targets Ther. 2021 Jan 25;14:667-682. doi: 10.2147/OTT.S281157. PMID: 33531815; PMCID: PMC7846877. 12: Carter NS, Stamper BD, Elbarbry F, Nguyen V, Lopez S, Kawasaki Y, Poormohamadian R, Roberts SC. Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise. Microorganisms. 2021 Jan 28;9(2):267. doi: 10.3390/microorganisms9020267. PMID: 33525448; PMCID: PMC7911663. 13: Kang X, Li C, Xie Y, He LL, Xiao F, Zhan KB, Tang YY, Li X, Tang XQ. Hippocampal ornithine decarboxylase/spermidine pathway mediates H2S-alleviated cognitive impairment in diabetic rats: Involving enhancment of hippocampal autophagic flux. J Adv Res. 2020 Jun 12;27:31-40. doi: 10.1016/j.jare.2020.06.007. PMID: 33318864; PMCID: PMC7728590. 14: Belayneh YM, Amare GG, Meharie BG. Updates on the molecular mechanisms of aspirin in the prevention of colorectal cancer: Review. J Oncol Pharm Pract. 2021 Jun;27(4):954-961. doi: 10.1177/1078155220984846. Epub 2021 Jan 11. PMID: 33427041. 15: Gruendler R, Hippe B, Sendula Jengic V, Peterlin B, Haslberger AG. Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review. Molecules. 2020 Dec 18;25(24):6018. doi: 10.3390/molecules25246018. PMID: 33353228; PMCID: PMC7765980. 16: Martel J, Chang SH, Wu CY, Peng HH, Hwang TL, Ko YF, Young JD, Ojcius DM. Recent advances in the field of caloric restriction mimetics and anti-aging molecules. Ageing Res Rev. 2021 Mar;66:101240. doi: 10.1016/j.arr.2020.101240. Epub 2020 Dec 24. PMID: 33347992. 17: Piñeyro MD, Arias D, Parodi-Talice A, Guerrero S, Robello C. Trypanothione Metabolism as Drug Target for Trypanosomatids. Curr Pharm Des. 2021;27(15):1834-1846. doi: 10.2174/1381612826666201211115329. PMID: 33308115. 18: Alcázar R, Bueno M, Tiburcio AF. Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance. Cells. 2020 Oct 29;9(11):2373. doi: 10.3390/cells9112373. PMID: 33138071; PMCID: PMC7692116. 19: Stacchiotti A, Corsetti G. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol. 2020 Sep 22;8:555409. doi: 10.3389/fcell.2020.555409. PMID: 33072744; PMCID: PMC7536349. 20: Adami R, Bottai D. S-adenosylmethionine tRNA modification: unexpected/unsuspected implications of former/new players. Int J Biol Sci. 2020 Sep 30;16(15):3018-3027. doi: 10.7150/ijbs.49302. PMID: 33061813; PMCID: PMC7545696.