Metacresol | CAS#108-39-4 | viscous liquid

MedKoo Cat#: 591604 | Name: Metacresol

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

meta-Cresol, also 3-methylphenol, is an organic compound with the formula CH₃C₆H₄. It is a colourless, viscous liquid that is used as an intermediate in the production of other chemicals.

Chemical Structure

Metacresol

CAS#108-39-4

Theoretical Analysis

MedKoo Cat#: 591604

Name: Metacresol

CAS#: 108-39-4

Chemical Formula: C7H8O

Exact Mass: 108.0575

Molecular Weight: 108.14

Elemental Analysis: C, 77.75; H, 7.46; O, 14.79

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks

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Related CAS #

No Data

Synonym

Metacresol; NSC 8768; NSC-8768; NSC8768

IUPAC/Chemical Name

Phenol, 3-methyl-

InChi Key

RLSSMJSEOOYNOY-UHFFFAOYSA-N

InChi Code

InChI=1S/C7H8O/c1-6-3-2-4-7(8)5-6/h2-5,8H,1H3

SMILES Code

OC1=CC=CC(C)=C1

Appearance

Liquid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

meta-Cresol is a colourless, viscous liquid that is used as an intermediate in the production of other chemicals.

In vitro activity:

In the range of m-cresol concentrations used in the study, specific growth rate of the culture and specific degradation rates were observed to follow substrate inhibition kinetics. Biokinetic constants estimated from these two models showed good potential of the indigenous mixed culture in degrading m-cresol in wastewaters. Reference: J Hazard Mater. 2009 Feb 15;162(1):476-81. https://pubmed.ncbi.nlm.nih.gov/18573608/

In vivo activity:

This study examined whether the RyR-mediated Ca(2+) release is involved in transmitter release at the rat calyx of Held synapse in brainstem slices. Bath application of 4-CmC (4-Chloro-m-cresol) caused a dramatic increase in the amplitude of excitatory postsynaptic currents (TIFCs) with the half-maximal effective concentration of 0.12 mm. 4-CmC markedly prolonged the duration of action potentials, with little effect on their rise time kinetics. Reference: Eur J Neurosci. 2007 Sep;26(6):1530-6. https://pubmed.ncbi.nlm.nih.gov/17714495/

Preparing Stock Solutions

The following data is based on the product molecular weight 108.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Saravanan P, Pakshirajan K, Saha P. Batch growth kinetics of an indigenous mixed microbial culture utilizing m-cresol as the sole carbon source. J Hazard Mater. 2009 Feb 15;162(1):476-81. doi: 10.1016/j.jhazmat.2008.05.069. Epub 2008 May 21. PMID: 18573608. 2. Suzuki D, Hori T, Saitoh N, Takahashi T. 4-Chloro-m-cresol, an activator of ryanodine receptors, inhibits voltage-gated K(+) channels at the rat calyx of Held. Eur J Neurosci. 2007 Sep;26(6):1530-6. doi: 10.1111/j.1460-9568.2007.05762.x. Epub 2007 Aug 20. PMID: 17714495. 3. Koizumi M, Noda A, Ito Y, Furukawa M, Fujii S, Kamata E, Ema M, Hasegawa R. Higher susceptibility of newborn than young rats to 3-methylphenol. J Toxicol Sci. 2003 May;28(2):59-70. doi: 10.2131/jts.28.59. PMID: 12820538.

In vitro protocol:

Saravanan P, Pakshirajan K, Saha P. Batch growth kinetics of an indigenous mixed microbial culture utilizing m-cresol as the sole carbon source. J Hazard Mater. 2009 Feb 15;162(1):476-81. doi: 10.1016/j.jhazmat.2008.05.069. Epub 2008 May 21. PMID: 18573608.

In vivo protocol:

1. Suzuki D, Hori T, Saitoh N, Takahashi T. 4-Chloro-m-cresol, an activator of ryanodine receptors, inhibits voltage-gated K(+) channels at the rat calyx of Held. Eur J Neurosci. 2007 Sep;26(6):1530-6. doi: 10.1111/j.1460-9568.2007.05762.x. Epub 2007 Aug 20. PMID: 17714495. 2. Koizumi M, Noda A, Ito Y, Furukawa M, Fujii S, Kamata E, Ema M, Hasegawa R. Higher susceptibility of newborn than young rats to 3-methylphenol. J Toxicol Sci. 2003 May;28(2):59-70. doi: 10.2131/jts.28.59. PMID: 12820538.

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PubMed PMID: 25655631; PubMed Central PMCID: PMC4543314. 15: Teska BM, Alarcón J, Pettis RJ, Randolph TW, Carpenter JF. Effects of phenol and meta-cresol depletion on insulin analog stability at physiological temperature. J Pharm Sci. 2014 Aug;103(8):2255-67. doi: 10.1002/jps.24039. Epub 2014 Jun 6. PubMed PMID: 24909933. 16: Kim MG, Jeon JH, Lee HS. Food protective effects of the active constituent isolated from Ostericum praeteritum against the stored food mite, Tyrophagus putrescentiae. J Food Prot. 2013 Nov;76(11):1887-91. doi: 10.4315/0362-028X.JFP-13-212. PubMed PMID: 24215692. 17: Zhang W, Wei C, Feng C, Ren Y, Hu Y, Yan B, Wu C. The occurrence and fate of phenolic compounds in a coking wastewater treatment plant. Water Sci Technol. 2013;68(2):433-40. doi: 10.2166/wst.2013.269. PubMed PMID: 23863439. 18: Hansen MJ, Adamsen AP, Feilberg A. Recovery of odorants from an olfactometer measured by proton-transfer-reaction mass spectrometry. 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