BMS-986318 is a a nonbile acid farnesoid X receptor (FXR) agonist (EC50 = 53 nM). BMS-986318 exhibits potent in vitro and in vivo activation of FXR, has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis. The overall profile of compound 1 supports its continued evaluation.
MedKoo Cat#: 465277
Name: BMS-986318
CAS#: 2314378-09-9
Chemical Formula: C30H23Cl2F3N4O3
Exact Mass: 614.1099
Molecular Weight: 615.43
Elemental Analysis: C, 58.55; H, 3.77; Cl, 11.52; F, 9.26; N, 9.10; O, 7.80
The following data is based on the product molecular weight 615.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
