BR-001 | CAS#unknown | EZH2 inihibitor

MedKoo Cat#: 465274 | Name: BR-001

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BR-001 is a EZH2 inihibitor. BR-001 displaced H3K27me3 with a low-nanomolar potency (IC50 = 0.0045 μM), and this activity translated well in a cellular setting (KARPAS422) where the compound dose dependently inhibited H3K27 trimethylation and cell viability.

Chemical Structure

BR-001

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465274

Name: BR-001

CAS#: unknown

Chemical Formula: C20H17D2FN4O2

Exact Mass: 368.1618

Molecular Weight: 368.41

Elemental Analysis: C, 65.20; H, 5.74; F, 5.16; N, 15.21; O, 8.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BR-001; BR001; BR 001;

IUPAC/Chemical Name

2-(((5-fluoro-2,3-dihydrobenzofuran-7-yl)methyl-d2)amino)-3-methyl-5-(2-methylpyridin-3-yl)pyrimidin-4(3H)-one

InChi Key

MXWWLBSTBNAQDF-KBMKNGFXSA-N

InChi Code

InChI=1S/C20H19FN4O2/c1-12-16(4-3-6-22-12)17-11-24-20(25(2)19(17)26)23-10-14-9-15(21)8-13-5-7-27-18(13)14/h3-4,6,8-9,11H,5,7,10H2,1-2H3,(H,23,24)/i10D2

SMILES Code

CC1=NC=CC=C1C2=CN=C(NC([2H])([2H])C3=C(OCC4)C4=CC(F)=C3)N(C)C2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 368.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dong H, Liu S, Zhang X, Chen S, Kang L, Chen Y, Ma S, Fu X, Liu Y, Zhang H, Zou B. An Allosteric PRC2 Inhibitor Targeting EED Suppresses Tumor Progression by Modulating the Immune Response. Cancer Res. 2019 Nov 1;79(21):5587-5596. doi: 10.1158/0008-5472.CAN-19-0428. Epub 2019 Aug 8. PMID: 31395608.