SB399885 HCl |CAS#402713-80-8 |402713-81-9 |SR-6 antagonist

MedKoo Cat#: 532666 | Name: SB399885 HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB 399885 hydrochloride is a potent, brain penetrant, and orally active SR-6 antagonist. It displays > 200-fold selectivity for SR-6 over other serotonin receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human SR-6 receptors, respectively).

Chemical Structure

SB399885 HCl

CAS#402713-81-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 532666

Name: SB399885 HCl

CAS#: 402713-81-9 (HCl)

Chemical Formula: C18H22Cl3N3O4S

Exact Mass: 0.0000

Molecular Weight: 482.80

Elemental Analysis: C, 44.78; H, 4.59; Cl, 22.03; N, 8.70; O, 13.26; S, 6.64

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 550.00	2 Weeks

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Related CAS #

402713-80-8(free base) 402713-81-9 (HCl)

Synonym

SB399885 HCl; SB399885; SB399885 Hydrochloride; SB 399885; SB-399885.

IUPAC/Chemical Name

N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamidehydrochloride

InChi Key

RNKCEBCFUSXSQE-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H21Cl2N3O4S.ClH/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2;/h3-4,9-11,21-22H,5-8H2,1-2H3;1H

SMILES Code

O=S(C1=CC=C(OC)C(N2CCNCC2)=C1)(NC3=CC(Cl)=CC(Cl)=C3OC)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 482.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Abraham R, Nirogi R, Shinde A, Benade VS. Therapeutic Potential of 5-HT6 Antagonist SB399885 in Traumatic Stress Disorder. Drug Res (Stuttg). 2015 Aug;65(8):442-5. doi: 10.1055/s-0034-1390418. Epub 2014 Oct 13. PubMed PMID: 25310249.