Synonym
Org 6582; Org6582; Org-6582
IUPAC/Chemical Name
(5S,9S,11R)-2-chloro-5,6,9,10-tetrahydro-5,9-methanobenzo[8]annulen-11-amine hydrochloride
InChi Key
LWRJZIPAGMGXQJ-POJHVLMBSA-N
InChi Code
InChI=1S/C13H14ClN.ClH/c14-10-4-5-11-9(7-10)6-8-2-1-3-12(11)13(8)15;/h1-2,4-5,7-8,12-13H,3,6,15H2;1H/t8-,12+,13-;/m1./s1
SMILES Code
N[C@@H]1[C@H]2Cc3c([C@@H]1CC=C2)ccc(Cl)c3.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
256.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sugrue MF, Goodlet I, Mireylees SE. On the selective inhibition of serotonin uptake in vivo by Org 6582. Eur J Pharmacol. 1976 Nov;40(1):121-30. doi: 10.1016/0014-2999(76)90361-7. PMID: 991921.
2: Vink J, van Hal HJ, van de Laar GL. Single ion monitoring assay for the serotonin re-uptake blocker Org 6582 in plasma. Biomed Mass Spectrom. 1982 Sep;9(9):370-5. doi: 10.1002/bms.1200090903. PMID: 7139056.
3: Mireylees SE, Goodlet I, Sugrue MF. Effects of ORG 6582 on monoamine uptake in vitro. Biochem Pharmacol. 1978 Apr 1;27(7):1023-7. doi: 10.1016/0006-2952(78)90152-1. PMID: 656149.
4: Goodlet I, Mireyless SE, Surgue MF. In vitro studies on the inhibition of monoamine uptake by Org 6582 [proceedings]. Br J Pharmacol. 1977 Mar;59(3):481P-482P. PMID: 843719; PMCID: PMC1668011.
5: Kafoe WF, Leonard BE. Effects of Org 6582, chlorimipramine and desmethylimipramine on the depletion of biogenic amines from the rat brain in vivo. Biochem Pharmacol. 1977 Jun 1;26(11):1083-4. doi: 10.1016/0006-2952(77)90248-9. PMID: 880260.
6: Goodlet I, Mireylees SE, Sugrue MF. Proceedings: The selective inhibition of 5-hydroxy-tryptamine re-uptake by Org 6582. Br J Pharmacol. 1976 Mar;56(3):367P-368P. PMID: 1260197; PMCID: PMC1666957.
7: Sugrue MF. Antagonism of fenfluramine-induced hyperthermia in rats by some, but not all, selective inhibitors of 5-hydroxytryptamine uptake. Br J Pharmacol. 1984 Apr;81(4):651-7. doi: 10.1111/j.1476-5381.1984.tb16131.x. PMID: 6722394; PMCID: PMC1986900.
8: Wilson GA, Furman BL. Effects of inhibitors of 5-hydroxytryptamine uptake on plasma glucose and their interaction with 5-hydroxytryptophan in producing hypoglycaemia in mice. Eur J Pharmacol. 1982 Mar 12;78(3):263-70. doi: 10.1016/0014-2999(82)90027-9. PMID: 7040087.
9: Pawłowski L, Kwiatek H, Górka Z. Is Ro 11-2465 (cyan-imipramine) an antagonist of postsynaptic serotonin receptors? J Neural Transm. 1981;52(1-2):61-72. doi: 10.1007/BF01253098. PMID: 7288439.
10: Hwang EC, Van Woert MH. Behavioral and biochemical effects of para- methoxyphenylethylamine. Res Commun Chem Pathol Pharmacol. 1979 Mar;23(3):419-31. PMID: 461968.
