MedKoo Cat#: 531757 | Name: CV-6209
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, with IC50 values of 75 and 170 nM, respectively. CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.

Chemical Structure

CV-6209
CV-6209
CAS#100488-87-7

Theoretical Analysis

MedKoo Cat#: 531757

Name: CV-6209

CAS#: 100488-87-7

Chemical Formula: C34H60ClN3O6

Exact Mass: 0.0000

Molecular Weight: 642.32

Elemental Analysis: C, 63.58; H, 9.42; Cl, 5.52; N, 6.54; O, 14.94

Price and Availability

Size Price Availability Quantity
1mg USD 425.00 Back order
5mg USD 1,250.00 Back order
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Related CAS #
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Synonym
CV-6209; CV 6209; CV6209; CV-6209 (chloride)
IUPAC/Chemical Name
2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium, monochloride
InChi Key
APUCCVGQZPNXIO-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H59N3O6.ClH/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2;/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3;1H
SMILES Code
O=C(N(CC1=CC=CC=[N+]1CC)C(OCC(COC(NCCCCCCCCCCCCCCCCCC)=O)OC)=O)C.[Cl-]
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 642.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Iwao Y, Takano T, Taneike I, Reva I, Isobe H, Zhang HM, Nishiyama A, Yamamoto T. Anti-Helicobacter pylori actions of CV-6209, a platelet-activating factor receptor antagonist. J Gen Appl Microbiol. 2013;59(2):147-52. PubMed PMID: 23759868. 2: Qayumi KA, English JC, Feeley EJ, Poostizadeh A, Nikbakht-Sangari M. A new platelet-activating factor antagonist (CV-6209) in preservation of heart and lung for transplantation. Cardiovasc Drugs Ther. 1997 Dec;11(6):777-85. PubMed PMID: 9512873. 3: Gupta JB, Prasad M, Kalra J, Prasad K. Platelet-activating-factor-induced changes in cardiovascular function and oxyradical status of myocardium in presence of the PAF antagonist CV-6209. Angiology. 1994 Jan;45(1):25-36. PubMed PMID: 8285381.