VU6028418 | CAS#2649803-05-2 | M4 mAChR antagonist

MedKoo Cat#: 465271 | Name: VU6028418

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU6028418 is a Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor (mAChR) Antagonist. VU6028418 was subsequently evaluated as a preclinical candidate for the treatment of dystonia and other movement disorders.

Chemical Structure

VU6028418

CAS#2649803-05-2

Theoretical Analysis

MedKoo Cat#: 465271

Name: VU6028418

CAS#: 2649803-05-2

Chemical Formula: C23H27F3N4O

Exact Mass: 432.2137

Molecular Weight: 432.49

Elemental Analysis: C, 63.87; H, 6.29; F, 13.18; N, 12.95; O, 3.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VU6028418; VU 6028418; VU-6028418;

IUPAC/Chemical Name

(3aR,5s,6aS)-2-((tetrahydro-2H-pyran-4-yl)methyl)-N-(6-(2,3,5-trifluorophenyl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine

InChi Key

ITSKPCHXUYILTR-VQFNDLOPSA-N

InChi Code

InChI=1S/C23H27F3N4O/c24-17-9-19(23(26)20(25)10-17)21-1-2-22(29-28-21)27-18-7-15-12-30(13-16(15)8-18)11-14-3-5-31-6-4-14/h1-2,9-10,14-16,18H,3-8,11-13H2,(H,27,29)/t15-,16+,18+

SMILES Code

FC1=CC(F)=C(F)C(C2=CC=C(N[C@H]3C[C@@](CN(C([H])([H])C4CCOCC4)C5)([H])[C@@]5([H])C3)N=N2)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

May 7, 2024- Product VU6028418 Patent licensing News MedKoo is excited to announce the licensing of patents of the novel compound VU6028418 from Vanderbilt University. VU6028418, a breakthrough compound, is now featured on our website at https://www.medkoo.com/products/48056. VU6028418 is a Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor (mAChR) Antagonist. VU6028418 was subsequently evaluated as a preclinical candidate for the treatment of dystonia and other movement disorders. . This groundbreaking product is safeguarded by patents including WO 2021/119265 A1.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 432.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Suwa A, Konishi Y, Uruno Y, Takai K, Nakako T, Sakai M, Enomoto T, Ochi Y, Matsuda H, Kitamura A, Uematsu Y, Kiyoshi A, Sumiyoshi T. Discovery of N-sulfonyl-7-azaindoline derivatives as potent, orally available and selective M(4) muscarinic acetylcholine receptor agonists. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2909-12. doi: 10.1016/j.bmcl.2014.04.083. Epub 2014 May 9. PMID: 24852118.