Mequitazine sulfoxide | CAS# 40765-34-2 | Biochemical

MedKoo Cat#: 577144 | Name: Mequitazine sulfoxide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mequitazine sulfoxide is a potent histamine H1 antagonist or antihistamine.

Chemical Structure

Mequitazine sulfoxide

CAS#40765-34-2

Theoretical Analysis

MedKoo Cat#: 577144

Name: Mequitazine sulfoxide

CAS#: 40765-34-2

Chemical Formula: C20H22N2OS

Exact Mass: 338.1453

Molecular Weight: 338.47

Elemental Analysis: C, 70.97; H, 6.55; N, 8.28; O, 4.73; S, 9.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LM 209 SO; LM-209 SO; LM209 SO; Mequitazine sulfoxide

IUPAC/Chemical Name

10H-Phenothiazine, 10-(3-quinuclidinylmethyl)-, 5-oxide

InChi Key

GWHIBUGIPBSCCU-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H22N2OS/c23-24-19-7-3-1-5-17(19)22(18-6-2-4-8-20(18)24)14-16-13-21-11-9-15(16)10-12-21/h1-8,15-16H,9-14H2

SMILES Code

O=S1c2ccccc2N(CC3CN4CCC3CC4)c5ccccc15

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 338.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ahn SH, Maeng HJ. Quantification of mequitazine in human plasma by gas chromatography- quadrupole mass spectrometry and its application to a human pharmacokinetic study. Biomed Chromatogr. 2016 Apr;30(4):574-8. doi: 10.1002/bmc.3585. Epub 2015 Sep 20. PubMed PMID: 26268745. 2: Leroux S, Larquetoux L, Nicolas M, Doris E. Asymmetric synthesis of (+)-mequitazine from quinine. Org Lett. 2011 Jul 1;13(13):3549-51. doi: 10.1021/ol2012567. Epub 2011 Jun 9. PubMed PMID: 21657243. 3: Gonnot V, Nicolas M, Mioskowski C, Baati R. Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate. Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1300-2. PubMed PMID: 19881287. 4: Abdel-Moety EM, Ibrahim MA, Rezk MR. Photodegradation and photostability-indication of mequitazine. Spectrochim Acta A Mol Biomol Spectrosc. 2009 Oct 15;74(3):740-5. doi: 10.1016/j.saa.2009.08.006. Epub 2009 Aug 12. PubMed PMID: 19729339. 5: Kumazawa T, Hasegawa C, Lee XP, Marumo A, Shimmen N, Ishii A, Seno H, Sato K. Pipette tip solid-phase extraction and gas chromatography-mass spectrometry for the determination of mequitazine in human plasma. Talanta. 2006 Sep 15;70(2):474-8. doi: 10.1016/j.talanta.2006.02.059. Epub 2006 May 2. PubMed PMID: 18970795.