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MedKoo Cat#: 466105 | Name: CMG002

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CMG002 is a PI3K and mTOR inhibitor.

Chemical Structure

CMG002
CMG002
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466105

Name: CMG002

CAS#: unknown

Chemical Formula: C27H26ClF2N7O4S

Exact Mass: 617.1424

Molecular Weight: 618.06

Elemental Analysis: C, 52.47; H, 4.24; Cl, 5.74; F, 6.15; N, 15.86; O, 10.35; S, 5.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
CMG002; CMG 002; CMG-002;
IUPAC/Chemical Name
isopropyl 4-((6-(6-chloro-5-((2,4-difluorophenyl)sulfonamido)pyridin-3-yl)pyrido[3,2-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
InChi Key
NERMYQPTYCTEDU-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H26ClF2N7O4S/c1-15(2)41-27(38)37-9-7-18(8-10-37)34-26-24-21(32-14-33-26)5-4-20(35-24)16-11-22(25(28)31-13-16)36-42(39,40)23-6-3-17(29)12-19(23)30/h3-6,11-15,18,36H,7-10H2,1-2H3,(H,32,33,34)
SMILES Code
FC1=CC=C(S(NC2=C(Cl)N=CC(C3=NC4=C(NC5CCN(C(OC(C)C)=O)CC5)N=CN=C4C=C3)=C2)(=O)=O)C(F)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 618.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim MN, Lee SM, Kim JS, Hwang SG. Preclinical efficacy of a novel dual PI3K/mTOR inhibitor, CMG002, alone and in combination with sorafenib in hepatocellular carcinoma. Cancer Chemother Pharmacol. 2019 Oct;84(4):809-817. doi: 10.1007/s00280-019-03918-y. Epub 2019 Aug 5. PMID: 31385002. 2: Kim MY, Kruger AJ, Jeong JY, Kim J, Shin PK, Kim SY, Cho JY, Hahm KB, Hong SP. Combination Therapy with a PI3K/mTOR Dual Inhibitor and Chloroquine Enhances Synergistic Apoptotic Cell Death in Epstein-Barr Virus-Infected Gastric Cancer Cells. Mol Cells. 2019 Jun 30;42(6):448-459. doi: 10.14348/molcells.2019.2395. PMID: 31085812; PMCID: PMC6602147. 3: Choi HJ, Heo JH, Park JY, Jeong JY, Cho HJ, Park KS, Kim SH, Moon YW, Kim JS, An HJ. A novel PI3K/mTOR dual inhibitor, CMG002, overcomes the chemoresistance in ovarian cancer. Gynecol Oncol. 2019 Apr;153(1):135-148. doi: 10.1016/j.ygyno.2019.01.012. Epub 2019 Jan 25. PMID: 30686552.