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MedKoo Cat#: 414592 | Name: OPC-14117 2HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OPC-14117 2HCl is an antioxidant that has both brain function activating effect and protective effect against cerebral ischemia.

Chemical Structure

OPC-14117 2HCl
OPC-14117 2HCl
CAS#103247-40-1 (2HCl)

Theoretical Analysis

MedKoo Cat#: 414592

Name: OPC-14117 2HCl

CAS#: 103247-40-1 (2HCl)

Chemical Formula: C26H37Cl2N3O3

Exact Mass: 509.2212

Molecular Weight: 510.50

Elemental Analysis: C, 61.17; H, 7.31; Cl, 13.89; N, 8.23; O, 9.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
103247-40-1 (2HCl); 103233-65-4 (free base)
Synonym
OPC-14117 dihydrochloride; OPC-14117 2HCl; OPC-14117-dihcl; OPC14117-dihcl; OPC 14117-dihcl; OPC14117 2HCl; OPC 14117 2HCl; OPC-14117 2HCl
IUPAC/Chemical Name
1-Piperazineacetamide, N-(2,3-dihydro-7-hydroxy-2,2,4,6-tetramethyl-1H-inden-1-yl)-4-(3-methoxyphenyl)-, hydrochloride (1:2)
InChi Key
FJPBWCKDHZPVFB-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H35N3O3.2ClH/c1-17-13-18(2)24(31)23-21(17)15-26(3,4)25(23)27-22(30)16-28-9-11-29(12-10-28)19-7-6-8-20(14-19)32-5;;/h6-8,13-14,25,31H,9-12,15-16H2,1-5H3,(H,27,30);2*1H
SMILES Code
O=C(NC1C(C)(C)CC2=C1C(O)=C(C)C=C2C)CN3CCN(C4=CC=CC(OC)=C4)CC3.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 510.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nakai M, Qin ZH, Wang Y, Chase TN. Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kappaB activation and apoptosis in rat striatum. Brain Res Mol Brain Res. 1999 Jan 22;64(1):59-68. PubMed PMID: 9889320. 2: Aoyama N, Katayama Y, Kawamata T, Maeda T, Mori T, Yamamoto T, Kikuchi T, Uwahodo Y. Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat. Brain Res. 2002 May 3;934(2):117-24. PubMed PMID: 11955474. 3: Jinno J, Mori H, Oshiro Y, Kikuchi T, Sakurai H. Evaluation of superoxide scavenging activity of OPC-14117 by electron spin resonance technique. Free Radic Res Commun. 1991;15(4):223-30. PubMed PMID: 1667773. 4: Fisher M, Arpano MM. Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117. J Neurol Sci. 1992 May;109(1):107-10. PubMed PMID: 1517759. 5: Abe K, Morita S, Kikuchi T, Itoyama Y. Protective effect of a novel free radical scavenger, OPC-14117, on wobbler mouse motor neuron disease. J Neurosci Res. 1997 Apr 1;48(1):63-70. PubMed PMID: 9086182. 6: Nakai M, Qin Z, Wang Y, Chase TN. NMDA and non-NMDA receptor-stimulated IkappaB-alpha degradation: differential effects of the caspase-3 inhibitor DEVD.CHO, ethanol and free radical scavenger OPC-14117. Brain Res. 2000 Mar 24;859(2):207-16. PubMed PMID: 10719066. 7: Kawamata T, Katayama Y, Maeda T, Mori T, Aoyama N, Kikuchi T, Uwahodo Y. Antioxidant, OPC-14117, attenuates edema formation and behavioral deficits following cortical contusion in rats. Acta Neurochir Suppl. 1997;70:191-3. PubMed PMID: 9416319. 8: Mori T, Kawamata T, Katayama Y, Maeda T, Aoyama N, Kikuchi T, Uwahodo Y. Antioxidant, OPC-14117, attenuates edema formation, and subsequent tissue damage following cortical contusion in rats. Acta Neurochir Suppl. 1998;71:120-2. PubMed PMID: 9779162. 9: Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease. The Huntington Study Group. Neurology. 1998 May;50(5):1366-73. PubMed PMID: 9595988. 10: OPC 14117. Drugs R D. 1999 Jan;1(1):34-5. PubMed PMID: 10565980. 11: Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. Neurology. 1997 Jul;49(1):142-6. PubMed PMID: 9222182. 12: Otsubo K. [Studies on the efficient syntheses of the drug metabolites]. Yakugaku Zasshi. 2000 Nov;120(11):1135-47. Review. Japanese. PubMed PMID: 11190199. 13: Blanchet PJ, Konitsiotis S, Hyland K, Arnold LA, Pettigrew KD, Chase TN. Chronic exposure to MPTP as a primate model of progressive parkinsonism: a pilot study with a free radical scavenger. Exp Neurol. 1998 Oct;153(2):214-22. PubMed PMID: 9784281. 14: Oshiro Y, Sakurai Y, Tanaka T, Kikuchi T, Hirose T, Tottori K. Novel cerebroprotective agents with central nervous system stimulating activity. 2. Synthesis and pharmacology of the 1-(acylamino)-7-hydroxyindan derivatives. J Med Chem. 1991 Jul;34(7):2014-23. PubMed PMID: 1676757. 15: Vitamin E drug. Treat Rev. 1995 May;(no 18):1. PubMed PMID: 11362588.