Synonym
HP1328; HP 1328; HP-1328;
IUPAC/Chemical Name
2-(2-methoxy-4-(((1-phenyl-1H-benzo[d]imidazol-5-yl)amino)methyl)phenoxy)ethan-1-ol
InChi Key
FNNZOQPZURDRII-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H23N3O3/c1-28-23-13-17(7-10-22(23)29-12-11-27)15-24-18-8-9-21-20(14-18)25-16-26(21)19-5-3-2-4-6-19/h2-10,13-14,16,24,27H,11-12,15H2,1H3
SMILES Code
COC1=CC(CNC2=CC=C3N(C4=CC=CC=C4)C=NC3=C2)=CC=C1OCCO
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
389.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tian T, Zhang S, Luo B, Yin F, Lu W, Li Y, Huang K, Liu Q, Huang P, Garcia- Manero G, Wen S, Hu Y. Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library. J Med Chem. 2022 Feb 11. doi: 10.1021/acs.jmedchem.1c02079. Epub ahead of print. PMID: 35148084.
2: Waidner B, Melchers K, Ivanov I, Loferer H, Bensch KW, Kist M, Bereswill S. Identification by RNA profiling and mutational analysis of the novel copper resistance determinants CrdA (HP1326), CrdB (HP1327), and CzcB (HP1328) in Helicobacter pylori. J Bacteriol. 2002 Dec;184(23):6700-8. doi: 10.1128/JB.184.23.6700-6708.2002. PMID: 12426358; PMCID: PMC135432.
