Ontazolast | CAS# 147432-77-7 | LTB4 biosynthesis inhibitor

MedKoo Cat#: 414588 | Name: Ontazolast

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ontazolast is a potent inhibitor (IC50 = 1 nm) of calcium ionophore A23187-stimulated leukotriene B4 (LTB4) biosynthesis in human peripheral blood leukocytes.

Chemical Structure

Ontazolast

CAS#147432-77-7

Theoretical Analysis

MedKoo Cat#: 414588

Name: Ontazolast

CAS#: 147432-77-7

Chemical Formula: C21H25N3O

Exact Mass: 335.1998

Molecular Weight: 335.45

Elemental Analysis: C, 75.19; H, 7.51; N, 12.53; O, 4.77

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Synonym

Ontazolast; BIRM270; BIRM 270; BIRM-270

IUPAC/Chemical Name

2-Benzoxazolamine, N-(2-cyclohexyl-1-(2-pyridinyl)ethyl)-5-methyl-, (S)-

InChi Key

RVXKHAITGKBBAC-SFHVURJKSA-N

InChi Code

InChI=1S/C21H25N3O/c1-15-10-11-20-19(13-15)24-21(25-20)23-18(17-9-5-6-12-22-17)14-16-7-3-2-4-8-16/h5-6,9-13,16,18H,2-4,7-8,14H2,1H3,(H,23,24)/t18-/m0/s1

SMILES Code

CC1=CC=C(OC(N[C@H](C2=NC=CC=C2)CC3CCCCC3)=N4)C4=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 335.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hauss DJ, Fogal SE, Ficorilli JV, Price CA, Roy T, Jayaraj AA, Keirns JJ. Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor. J Pharm Sci. 1998 Feb;87(2):164-9. doi: 10.1021/js970300n. PMID: 9519148. 2: Hamlin RL, Nakayama T, Brady JT, Stoll RE. Hemodynamic and electrophysiologic effects of ontazolast in dogs. Am J Vet Res. 2000 Nov;61(11):1364-8. doi: 10.2460/ajvr.2000.61.1364. PMID: 11108180. 3: Hamlin RL, Cruze CA, Mittelstadt SW, Kijtawornrat A, Keene BW, Roche BM, Nakayama T, Nakayama H, Hamlin DM, Arnold T. Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc. J Pharmacol Toxicol Methods. 2004 Jan-Feb;49(1):15-23. doi: 10.1016/j.vascn.2003.08.003. PMID: 14670690. 4: Abrahamyan L, Sahakyan Y, Wijeysundera HC, Krahn M, Rac VE. Gender Differences in Utilization of Specialized Heart Failure Clinics. J Womens Health (Larchmt). 2018 May;27(5):623-629. doi: 10.1089/jwh.2017.6461. Epub 2018 Jan 10. PMID: 29319404. 5: Parks TP, Hoffman AF, Homon CA, Graham AG, Lazer ES, Chilton FH, Borgeat P, Raible D, Schulman E, Bass DA, et al. Inhibition of lipid mediator biosynthesis in human inflammatory cells by BIRM 270. Agents Actions Suppl. 1995;46:139-46. doi: 10.1007/978-3-0348-7276-8_14. PMID: 7610984. 6: Hall RE, Khan F, Bayley MT, Asllani E, Lindsay P, Hill MD, O'Callaghan C, Silver FL, Kapral MK. Benchmarks for acute stroke care delivery. Int J Qual Health Care. 2013 Dec;25(6):710-8. doi: 10.1093/intqhc/mzt069. Epub 2013 Oct 17. PMID: 24141011; PMCID: PMC3842126. 7: Farina PR, Graham AG, Hoffman AF, Watrous JM, Borgeat P, Nadeau M, Hansen G, Dinallo RM, Adams J, Miao CK, et al. BIRM 270: a novel inhibitor of arachidonate release that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. J Pharmacol Exp Ther. 1994 Dec;271(3):1418-26. PMID: 7996454.