Orphenadrine citrate | CAS# 4682-36-4 (citrate) | Antihistaminic and Skeletal Muscle Relaxant

MedKoo Cat#: 414478 | Name: Orphenadrine citrate

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Orphenadrine citrate is an Antihistaminic and Skeletal Muscle Relaxant.

Chemical Structure

Orphenadrine citrate

CAS#4682-36-4 (citrate)

Theoretical Analysis

MedKoo Cat#: 414478

Name: Orphenadrine citrate

CAS#: 4682-36-4 (citrate)

Chemical Formula: C24H31NO8

Exact Mass: 0.0000

Molecular Weight: 461.51

Elemental Analysis: C, 62.46; H, 6.77; N, 3.04; O, 27.73

Price and Availability

Size	Price	Availability	Quantity
1g	USD 250.00	2 Weeks
5g	USD 550.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

4682-36-4 (citrate); 341-69-5 (HCl) 83-98-7 (free base)

Synonym

Orphenadrine citrate; Banflex; Benhexal; NSC757238; NSC-757238; NSC 757238

IUPAC/Chemical Name

Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

InChi Key

MMMNTDFSPSQXJP-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H23NO.C6H8O7/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-12,18H,13-14H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES Code

CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.O=C(CC(C(O)=O)(O)CC(O)=O)O

Appearance

Solid powder

Purity

>97% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 461.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bayazeid O, Nemutlu E, Eylem CC, İlhan M, Küpeli-Akkol E, Karahan H, Kelicen- Uğur P, Ersoz T, Yalçın FN. Neuroactivity of the naturally occurring aporphine alkaloid, roemerine. Nat Prod Res. 2020 Oct 7:1-6. doi: 10.1080/14786419.2020.1830395. Epub ahead of print. PMID: 33025828. 2: Roveri V, Guimarães LL, Toma W, Correia AT. Occurrence and ecological risk assessment of pharmaceuticals and cocaine in a beach area of Guarujá, São Paulo State, Brazil, under the influence of urban surface runoff. Environ Sci Pollut Res Int. 2020 Aug 10. doi: 10.1007/s11356-020-10316-y. Epub ahead of print. PMID: 32779066. 3: Cheah KY, Mah KY, Pang LH, Ng SM, Wong JW, Tan SS, Tan HZ, Yuen KH. A randomized single-dose, two-period crossover bioequivalence study of two fixed- dose Paracetamol/Orphenadrine combination preparations in healthy volunteers under fasted condition. BMC Pharmacol Toxicol. 2020 Jun 23;21(1):45. doi: 10.1186/s40360-020-00416-3. PMID: 32576287; PMCID: PMC7310552. 4: Borowy CS, Mukherji P. Antihistamine Toxicity. 2020 Jun 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 29493943. 5: Al Khaja KAJ, James H, Veeramuthu S, Tayem YI, Sridharan K, Sequeira RP. Prevalence of drugs with constipation-inducing potential and laxatives in community-dwelling older adults in Bahrain: therapeutic implications. Int J Pharm Pract. 2020 Oct;28(5):466-472. doi: 10.1111/ijpp.12636. Epub 2020 May 10. PMID: 32390165. 6: Dander JE, Giroud M, Racine S, Darzi ER, Alvizo O, Entwistle D, Garg NK. Chemoenzymatic conversion of amides to enantioenriched alcohols in aqueous medium. Commun Chem. 2019;2(1):10.1038/s42004-019-0182-8. doi: 10.1038/s42004-019-0182-8. Epub 2019 Jul 19. PMID: 32042928; PMCID: PMC7010078. 7: Abd-Elsalam S, Ebrahim S, Soliman S, Alkhalawany W, Elfert A, Hawash N, Elkadeem M, Badawi R. Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study. Eur J Gastroenterol Hepatol. 2019 Dec 9. doi: 10.1097/MEG.0000000000001622. Epub ahead of print. PMID: 31834056. 8: Boltia SA, Soudi AT, Elzanfaly ES, Zaazaa HE. Development and Validation of Chromatographic Methods for Simultaneous Determination of Paracetamol, Orphenadrine Citrate and Caffeine in Presence of P-aminophenol; Quantification of P-aminophenol Nephrotoxic Impurity Using LC-MS/MS. J Chromatogr Sci. 2020 Apr 22;58(3):223-233. doi: 10.1093/chromsci/bmz094. PMID: 31812988. 9: Sebaiy MM, El-Adl SM, Mattar AA. Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 5;224:117429. doi: 10.1016/j.saa.2019.117429. Epub 2019 Jul 26. PMID: 31394394. 10: Boltia SA, Soudi AT, Elzanfaly ES, Zaazaa HE. Effect of Genetic Algorithm- Based Wavelength Selection as a Preprocessing Tool on Multivariate Simultaneous Determination of Paracetamol, Orphenadrine Citrate, and Caffeine in the Presence of p-Aminophenol Impurity. J AOAC Int. 2019 Jul 5. doi: 10.5740/jaoacint.18-0393. Epub ahead of print. PMID: 31277724. 11: Hamdan II, Kasabri VN, Al-Hiari YM, El-Sabawi D, Zalloum H. Pancreatic lipase inhibitory activity of selected pharmaceutical agents. Acta Pharm. 2019 Mar 1;69(1):1-16. doi: 10.2478/acph-2019-0010. PMID: 31259721. 12: Chaumont-Olive P, Rouen M, Barozzino-Consiglio G, Ben Abdeladhim A, Maddaluno J, Harrison-Marchand A. Chiral Lithium Amido Aryl Zincates: Simple and Efficient Chemo- and Enantio-Selective Aryl Transfer Reagents. Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3193-3197. doi: 10.1002/anie.201813510. Epub 2019 Jan 17. PMID: 30653791. 13: Abd-Elsalam S, El-Kalla F, Ali LA, Mosaad S, Alkhalawany W, Elemary B, Badawi R, Elzeftawy A, Hanafy A, Elfert A. Pilot study of orphenadrine as a novel treatment for muscle cramps in patients with liver cirrhosis. United European Gastroenterol J. 2018 Apr;6(3):422-427. doi: 10.1177/2050640617731261. Epub 2017 Sep 6. PMID: 29774156; PMCID: PMC5949967. 14: Katselou M, Athanaselis S, Nikolaou P, Qammaz S, Dona A, Spiliopoulou C, Papoutsis I. A fully validated method for the simultaneous determination of 11 antihistamines in breast milk by gas chromatography-mass spectrometry. Biomed Chromatogr. 2018 Aug;32(8):e4260. doi: 10.1002/bmc.4260. Epub 2018 May 28. PMID: 29644705. 15: Moody DE, Fu Y, Fang WB. Inhibition of In Vitro Metabolism of Opioids by Skeletal Muscle Relaxants. Basic Clin Pharmacol Toxicol. 2018 Sep;123(3):327-334. doi: 10.1111/bcpt.12999. Epub 2018 Apr 19. PMID: 29504673. 16: Al Khaja KAJ, Ahmed Isa H, Veeramuthu S, Sequeira RP. Potentially Inappropriate Prescribing in Older Adults with Hypertension or Diabetes Mellitus and Hypertension in a Primary Care Setting in Bahrain. Med Princ Pract. 2018;27(3):241-249. doi: 10.1159/000488055. Epub 2018 Mar 1. PMID: 29495011; PMCID: PMC6062721. 17: Bergman H, Soares-Weiser K. Anticholinergic medication for antipsychotic- induced tardive dyskinesia. Cochrane Database Syst Rev. 2018 Jan 17;1(1):CD000204. doi: 10.1002/14651858.CD000204.pub2. PMID: 29341071; PMCID: PMC6491293. 18: Chinnery PF. Neuroferritinopathy. 2005 Apr 25 [updated 2018 Jan 18]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2020. PMID: 20301320. 19: Friedman BW, Cisewski D, Irizarry E, Davitt M, Solorzano C, Nassery A, Pearlman S, White D, Gallagher EJ. A Randomized, Double-Blind, Placebo- Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. Ann Emerg Med. 2018 Mar;71(3):348-356.e5. doi: 10.1016/j.annemergmed.2017.09.031. Epub 2017 Oct 28. PMID: 29089169; PMCID: PMC5820149. 20: Polito NB, Fellows SE. Pharmacologic Interventions for Intractable and Persistent Hiccups: A Systematic Review. J Emerg Med. 2017 Oct;53(4):540-549. doi: 10.1016/j.jemermed.2017.05.033. PMID: 29079070.

View History

Lipid C24