Recilisib Free Base | CAS# 334969-03-8 (free base) | protein kinase inhibitor and an apoptosis inhibitor

MedKoo Cat#: 414574 | Name: Recilisib Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Recilisib Free Base was a non-steroidal, small molecule, protein kinase inhibitor and an apoptosis inhibitor which protects against radiation damage from cancer

Chemical Structure

Recilisib Free Base

CAS#334969-03-8 (free base)

Theoretical Analysis

MedKoo Cat#: 414574

Name: Recilisib Free Base

CAS#: 334969-03-8 (free base)

Chemical Formula: C16H13ClO4S

Exact Mass: 336.0223

Molecular Weight: 336.79

Elemental Analysis: C, 57.06; H, 3.89; Cl, 10.53; O, 19.00; S, 9.52

Price and Availability

Size	Price	Availability	Quantity

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

334969-03-8 (free base) 922139-31-9 (sodium)

Synonym

Recilisib Free Base; ON01210; ON-01210; ON 01210

IUPAC/Chemical Name

Benzoic acid, 4-((1E)-2-(((4-chlorophenyl)methyl)sulfonyl)ethenyl)-

InChi Key

KBEKQQJUNVQLDZ-MDZDMXLPSA-N

InChi Code

InChI=1S/C16H13ClO4S/c17-15-7-3-13(4-8-15)11-22(20,21)10-9-12-1-5-14(6-2-12)16(18)19/h1-10H,11H2,(H,18,19)/b10-9+

SMILES Code

O=C(O)C1=CC=C(/C=C/S(=O)(CC2=CC=C(Cl)C=C2)=O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 336.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chen B, Chen Q, Lu M, Zou E, Lin G, Yao J, Wang L, Gan Y, Chen B, Chen G, Wu L. Hypocrellin A against intrahepatic Cholangiocarcinoma via multi-target inhibition of the PI3K-AKT-mTOR, MAPK, and STAT3 signaling pathways. Phytomedicine. 2024 Sep 7;135:156022. doi: 10.1016/j.phymed.2024.156022. Epub ahead of print. PMID: 39284270. 2: Shu Z, Li X, Zhang W, Huyan Z, Cheng D, Xie S, Cheng H, Wang J, Du B. MG-132 activates sodium palmitate-induced autophagy in human vascular smooth muscle cells and inhibits senescence via the PI3K/AKT/mTOR axis. Lipids Health Dis. 2024 Sep 4;23(1):282. doi: 10.1186/s12944-024-02268-w. PMID: 39232759; PMCID: PMC11373134. 3: Lu J, Shi X, Fu Q, Han Y, Zhu L, Zhou Z, Li Y, Lu N. New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling. Cell Mol Biol Lett. 2024 Jul 8;29(1):100. doi: 10.1186/s11658-024-00614-5. PMID: 38977961; PMCID: PMC11232284. 4: Li N, Wang XL, Ge R, Wang Y, Tian XL, Zhu GQ, Zhou B. FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway. J Cell Physiol. 2024 Jun;239(6):e31267. doi: 10.1002/jcp.31267. Epub 2024 Apr 1. PMID: 38558303. 5: Tian J, Li Y, Mao X, Xie K, Zheng Y, Yu Y, Yu Y. Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model. Int Immunopharmacol. 2023 Nov;124(Pt B):111063. doi: 10.1016/j.intimp.2023.111063. Epub 2023 Oct 17. PMID: 37857120. 6: Geng X, Zou Y, Li J, Li S, Qi R, Yu H, Zhong L. BDNF alleviates Parkinson's disease by promoting STAT3 phosphorylation and regulating neuronal autophagy. Cell Tissue Res. 2023 Sep;393(3):455-470. doi: 10.1007/s00441-023-03806-1. Epub 2023 Jul 14. PMID: 37450039; PMCID: PMC10485099. 7: Gong Z, Lao D, Wu Y, Li T, Lv S, Mo X, Huang W. Inhibiting PI3K/Akt-Signaling Pathway Improves Neurobehavior Changes in Anti-NMDAR Encephalitis Mice by Ameliorating Blood-Brain Barrier Disruption and Neuronal Damage. Cell Mol Neurobiol. 2023 Oct;43(7):3623-3637. doi: 10.1007/s10571-023-01371-3. Epub 2023 Jun 14. PMID: 37314618; PMCID: PMC10477152. 8: Liu Z, Yang Z, He L. Effect of miR‑29a‑3p in exosomes on glioma cells by regulating the PI3K/AKT/HIF‑1α pathway. Mol Med Rep. 2023 Mar;27(3):72. doi: 10.3892/mmr.2023.12959. Epub 2023 Feb 17. PMID: 36799154; PMCID: PMC9942261. 9: Lv G, Wang W, Sun M, Wang F, Ma Y, Li C. Inhibiting specificity protein 1 attenuated sevoflurane-induced mitochondrial stress and promoted autophagy in hippocampal neurons through PI3K/Akt/mTOR and α7-nAChR signaling. Neurosci Lett. 2023 Jan 18;794:136995. doi: 10.1016/j.neulet.2022.136995. Epub 2022 Dec 1. PMID: 36464148. 10: Dong J, Guo C, Zhou S, Bao T, Li J, Mi Y, Zhang C. Autophagy participates in germline cyst breakdown and follicular formation by modulating glycolysis switch via Akt signaling in newly-hatched chicken ovaries. Dev Biol. 2022 Jul;487:122-133. doi: 10.1016/j.ydbio.2022.04.013. Epub 2022 May 4. PMID: 35525303. 11: Ahmadi R, Emami S. Recent applications of vinyl sulfone motif in drug design and discovery. Eur J Med Chem. 2022 Apr 15;234:114255. doi: 10.1016/j.ejmech.2022.114255. Epub 2022 Mar 8. PMID: 35305462. 12: Liu J, Xu H, Wang N, Sun M. miR-15b, a diagnostic biomarker and therapeutic target, inhibits oesophageal cancer progression by regulating the PI3K/AKT signalling pathway. Exp Ther Med. 2020 Dec;20(6):222. doi: 10.3892/etm.2020.9352. Epub 2020 Oct 15. PMID: 33363587; PMCID: PMC7646696. 13: Huang J, Jiang R, Chu X, Wang F, Sun X, Wang Y, Pang L. Overexpression of microRNA-23a-5p induces myocardial infarction by promoting cardiomyocyte apoptosis through inhibited of PI3K/AKT signalling pathway. Cell Biochem Funct. 2020 Dec;38(8):1047-1055. doi: 10.1002/cbf.3536. Epub 2020 Jun 9. PMID: 32519337. 14: Zhang Y, Liu JL, Wang J. KRAS gene silencing inhibits the activation of PI3K-Akt-mTOR signaling pathway to regulate breast cancer cell epithelial- mesenchymal transition, proliferation and apoptosis. Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):3085-3096. doi: 10.26355/eurrev_202003_20673. PMID: 32271426.