Synonym
OKY 1581; OKY1581; OKY-1581
IUPAC/Chemical Name
2-Propenoic acid, 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-, sodium salt, (E)-
InChi Key
ZAPOSLLMEZKFQS-NBYYMMLRSA-M
InChi Code
InChI=1S/C16H15NO2.Na/c1-12(16(18)19)9-13-4-6-14(7-5-13)10-15-3-2-8-17-11-15;/h2-9,11H,10H2,1H3,(H,18,19);/q;+1/p-1/b12-9+;
SMILES Code
O=C([O-])/C(C)=C/C1=CC=C(CC2=CC=CN=C2)C=C1.[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
275.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Watanabe T, Utsugi M, Mitsukawa M, Suga T, Fujitani H. Hypolipidemic effect and enhancement of peroxisomal beta-oxidation in the liver of rats by sodium-(E)-3-(4-(3-pyridylmethyl)phenyl)-2-methyl propenoate (OKY-1581), a potent inhibitor of TxA2 synthetase. J Pharmacobiodyn. 1986 Dec;9(12):1023-31. doi: 10.1248/bpb1978.9.1023. PMID: 3572715.
2: Garcia-Szabo R, Kern DF, Malik AB. Pulmonary vascular response to thrombin: effects of thromboxane synthetase inhibition with OKY-046 and OKY-1581. Prostaglandins. 1984 Dec;28(6):851-66. doi: 10.1016/0090-6980(84)90039-x. PMID: 6543018.
3: Sasaki T, Wakai S, Asano T, Takakura K, Sano K. Prevention of cerebral vasospasm after SAH with a thromboxane synthetase inhibitor, OKY-1581. J Neurosurg. 1982 Jul;57(1):74-82. doi: 10.3171/jns.1982.57.1.0074. PMID: 7201009.
4: Casey LC, Fletcher JR, Zmudka MI, Ramwell PW. Prevention of endotoxin-induced pulmonary hypertension in primates by the use of a selective thromboxane synthetase inhibitor, OKY 1581. J Pharmacol Exp Ther. 1982 Aug;222(2):441-6. PMID: 6896528.
5: Tilden SJ, Underwood DC, Cowen KH, Wegmann MJ, Graybar GB, Hyman AL, McNamara DB, Kadowitz PJ. Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2. J Appl Physiol (1985). 1987 May;62(5):2066-74. doi: 10.1152/jappl.1987.62.5.2066. PMID: 2954941.
6: Rosenblum WI, El-Sabban F. Effect of OKY-1581, a thromboxane synthesis inhibitor, on the platelet aggregation and vasodilation induced by injury of mouse pial arterioles. J Cereb Blood Flow Metab. 1983 Mar;3(1):122-6. doi: 10.1038/jcbfm.1983.15. PMID: 6681612.
7: Uotila P, Matintalo M, Dahl ML. Arachidonic acid induced platelet aggregation and thromboxane formation is inhibited by OKY-1581. Prostaglandins Leukot Med. 1983 Nov;12(3):299-303. doi: 10.1016/0262-1746(83)90008-2. PMID: 6419237.
8: Guarner F, Boughton-Smith NK, Blackwell GJ, Moncada S. Reduction by prostacyclin of acetaminophen-induced liver toxicity in the mouse. Hepatology. 1988 Mar-Apr;8(2):248-53. doi: 10.1002/hep.1840080210. PMID: 3281885.
9: Waring PH, Hyman AL, Nandiwada PA, Kadowitz PJ. Influence of OKY-1581 on responses to arachidonic acid in the feline pulmonary vascular bed. Prostaglandins Leukot Essent Fatty Acids. 1988 Mar;31(3):117-22. doi: 10.1016/0952-3278(88)90107-x. PMID: 3131783.
10: Shea MJ, Driscoll EM, Romson JL, Pitt B, Lucchesi BR. Effect of OKY-1581, a thromboxane synthetase inhibitor, on coronary thrombosis in the conscious dog. Eur J Pharmacol. 1984 Oct 15;105(3-4):285-91. doi: 10.1016/0014-2999(84)90620-4. PMID: 6542526.
