Synonym
ROR Modulator I; ROR-Modulator-I; GUN13106; GUN-13106; GUN 13106;
IUPAC/Chemical Name
N-[5-(2-Chloro-benzoyl)-4-(3-chlorophenyl)-thiazol-2-yl]-2-(4-ethanesulfonyl-phenyl)-acetamide
InChi Key
GRWNPFJXINLSNF-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H20Cl2N2O4S2/c1-2-36(33,34)19-12-10-16(11-13-19)14-22(31)29-26-30-23(17-6-5-7-18(27)15-17)25(35-26)24(32)20-8-3-4-9-21(20)28/h3-13,15H,2,14H2,1H3,(H,29,30,31)
SMILES Code
O=C(NC1=NC(C2=CC=CC(Cl)=C2)=C(C(C3=CC=CC=C3Cl)=O)S1)CC4=CC=C(S(=O)(CC)=O)C=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
559.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lee J, Lee S, Chung S, Park N, Son GH, An H, Jang J, Chang DJ, Suh YG, Kim K. Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):580-6. doi: 10.1016/j.bbrc.2015.12.030. Epub 2015 Dec 12. PubMed PMID: 26692477.
2: Toyama H, Sato S, Shirakawa H, Komai M, Hashimoto Y, Fujii S. Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1817-20. doi: 10.1016/j.bmcl.2016.02.031. Epub 2016 Feb 12. PubMed PMID: 26905831.
3: Ding FM, Liao RM, Chen YQ, Xie GG, Zhang PY, Shao P, Zhang M. Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17 mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro. Mol Med Rep. 2017 Jul;16(1):778-786. doi: 10.3892/mmr.2017.6630. Epub 2017 May 25. PubMed PMID: 28560450; PubMed Central PMCID: PMC5482193.
4: Astafev AA, Patel SA, Kondratov RV. Calorie restriction effects on circadian rhythms in gene expression are sex dependent. Sci Rep. 2017 Aug 29;7(1):9716. doi: 10.1038/s41598-017-09289-9. PubMed PMID: 28851928; PubMed Central PMCID: PMC5575277.
5: Chang MR, Goswami D, Mercer BA, Griffin PR. The therapeutic potential of RORγ modulators in the treatment of human disease. J Exp Pharmacol. 2012 Oct 11;4:141-8. doi: 10.2147/JEP.S27078. eCollection 2012. Review. PubMed PMID: 27186126; PubMed Central PMCID: PMC4863310.
