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MedKoo Cat#: 577114 | Name: MEN-10573

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MEN-10573 is a cyclic pseudopeptide and potent tachykinin NK-2 receptor antagonist.

Chemical Structure

MEN-10573
MEN-10573
CAS#151911-03-4

Theoretical Analysis

MedKoo Cat#: 577114

Name: MEN-10573

CAS#: 151911-03-4

Chemical Formula: C45H56N8O8

Exact Mass: 836.4221

Molecular Weight: 836.99

Elemental Analysis: C, 64.58; H, 6.74; N, 13.39; O, 15.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
MEN10573; MEN 10573; MEN-10573
IUPAC/Chemical Name
benzyl 2-(11-((1H-indol-3-yl)methyl)-8-(3-amino-3-oxopropyl)-14-benzyl-2-isobutyl-6,9,12,15,19-pentaoxo-1,4,7,10,13,16-hexaazacyclononadecan-5-yl)acetate
InChi Key
QOHLOAJGFVUXEK-UHFFFAOYSA-N
InChi Code
InChI=1S/C45H56N8O8/c1-28(2)21-32-26-49-36(24-41(56)61-27-30-13-7-4-8-14-30)44(59)51-35(17-18-39(46)54)43(58)53-38(23-31-25-48-34-16-10-9-15-33(31)34)45(60)52-37(22-29-11-5-3-6-12-29)42(57)47-20-19-40(55)50-32/h3-16,25,28,32,35-38,48-49H,17-24,26-27H2,1-2H3,(H2,46,54)(H,47,57)(H,50,55)(H,51,59)(H,52,60)(H,53,58)
SMILES Code
CC(C)CC1CNC(CC(=O)OCc2ccccc2)C(=O)NC(CCC(=O)N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NC(Cc5ccccc5)C(=O)NCCC(=O)N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 836.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Maggi CA, Quartara L, Patacchini R, Giuliani S, Barbanti G, Turini D, Giachetti A. MEN 10,573 and MEN 10,612, novel cyclic pseudopeptides which are potent tachykinin NK-2 receptor antagonists. Regul Pept. 1993 Sep 3;47(2):151-8. doi: 10.1016/0167-0115(93)90419-9. PMID: 8234901. 2. Patacchini R, Giuliani S, Lazzeri M, Turini A, Quartara L, Maggi CA. Effect of several bicyclic peptide and cyclic pseudopeptide tachykinin NK2 receptor antagonists in the human isolated ileum and colon. Neuropeptides. 1997 Feb;31(1):71-7. doi: 10.1016/s0143-4179(97)90023-8. PMID: 9574841.

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