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MedKoo Cat#: 465000 | Name: GP-AMC HBr
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GP-AMC is a fluorogenic substrate for dipeptidyl peptidase 4 (DPP-4). Upon enzymatic cleavage by DPP-4, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify DPP-4 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

Chemical Structure

GP-AMC HBr
GP-AMC HBr
CAS#115035-46-6

Theoretical Analysis

MedKoo Cat#: 465000

Name: GP-AMC HBr

CAS#: 115035-46-6

Chemical Formula: C17H20BrN3O4

Exact Mass: 409.0637

Molecular Weight: 410.27

Elemental Analysis: C, 49.77; H, 4.91; Br, 19.48; N, 10.24; O, 15.60

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
GP-AMC HBr; GP AMC HBr; GPAMC HBr; GP-AMC hydrobromide; GPAMC; GP AMC; Gly-Pro-AMC; Gly-Pro-AMC (hydrobromide); H-GLY-PRO-AMC HBr; Gly-Pro-7-amido-4-methylcoumarin;
IUPAC/Chemical Name
(S)-1-glycyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)pyrrolidine-2-carboxamide hydrobromide
InChi Key
PASXTQMFJRHMLJ-ZOWNYOTGSA-N
InChi Code
InChI=1S/C17H19N3O4.BrH/c1-10-7-16(22)24-14-8-11(4-5-12(10)14)19-17(23)13-3-2-6-20(13)15(21)9-18;/h4-5,7-8,13H,2-3,6,9,18H2,1H3,(H,19,23);1H/t13-;/m0./s1
SMILES Code
CC(C1=CC=C(C=C1O2)NC([C@H]3N(CCC3)C(CN)=O)=O)=CC2=O.Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 10.0 24.37
DMSO 1.0 2.44
PBS (pH 7.2) 10.0 24.37
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 410.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang J, Qian XK, Song PF, Li XD, Wang AQ, Huo H, Yao JC, Zhang GM, Zou LW. A high-throughput screening assay for dipeptidyl peptidase-IV inhibitors using human plasma. Anal Methods. 2021 Jun 24;13(24):2671-2678. doi: 10.1039/d1ay00415h. PMID: 34036983.