Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = <1 nM). It is selective for ROCK2 over protein kinase A (PKA) and Cdc42-binding kinase (MRCKα; IC50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits phosphorylation of myosin light chain (MLC) in a cell-based assay (IC50 = <4 nM).
MedKoo Cat#: 464999
Name: Chroman 1 HCl hydrate
CAS#: Chroman 1 HCl hydrate
Chemical Formula: C24H32Cl2N4O5
Exact Mass: 526.1750
Molecular Weight: 527.44
Elemental Analysis: C, 54.65; H, 6.12; Cl, 13.44; N, 10.62; O, 15.17
Solvent | mg/mL | mM | comments | |
---|---|---|---|---|
Solubility | ||||
DMSO | 52.7 | 100.00 | ||
Water | 2.6 | 5.00 |
The following data is based on the product molecular weight 527.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |