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MedKoo Cat#: 577108 | Name: Meloxicam meglumine monohydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Meloxicam meglumine monohydrate is a non-steroidal anti-inflammatory agent and has been reported to inhibit the inducible isoform of Cox-2.

Chemical Structure

Meloxicam meglumine monohydrate
Meloxicam meglumine monohydrate
CAS#244241-53-0 (meglumine hydrate)

Theoretical Analysis

MedKoo Cat#: 577108

Name: Meloxicam meglumine monohydrate

CAS#: 244241-53-0 (meglumine hydrate)

Chemical Formula: C21H32N4O10S2

Exact Mass: 564.1560

Molecular Weight: 564.62

Elemental Analysis: C, 44.67; H, 5.71; N, 9.92; O, 28.34; S, 11.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
71125-39-8 (sodium hydrate) 244241-53-0 (meglumine hydrate) 244241-52-9 (meglumine) 71125-38-7
Synonym
Meloxicam meglumine monohydrate
IUPAC/Chemical Name
D-Glucitol, 1-deoxy-1-(methylamino)-, compd. with 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (1:1), monohydrate
InChi Key
SDOHSQSLGJYQKT-BMWGJIJESA-N
InChi Code
InChI=1S/C14H13N3O4S2.C7H17NO5.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;1-8-2-4(10)6(12)7(13)5(11)3-9;/h3-7,18H,1-2H3,(H,15,16,19);4-13H,2-3H2,1H3;1H2/t;4-,5+,6+,7+;/m.0./s1
SMILES Code
O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ncc(C)s3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 564.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Low-dose meloxicam (Vivlodex) for osteoarthritis pain. Med Lett Drugs Ther. 2016 Mar 14;58(1490):35-6. PubMed PMID: 26963155. 2: Almukainzi M, Jamali F, Aghazadeh-Habashi A, Löbenberg R. Disease specific modeling: Simulation of the pharmacokinetics of meloxicam and ibuprofen in disease state vs. healthy conditions. Eur J Pharm Biopharm. 2016 Mar;100:77-84. doi: 10.1016/j.ejpb.2015.12.004. Epub 2016 Jan 2. PubMed PMID: 26752427. 3: Alomrani AH, Badran MM. Flexosomes for transdermal delivery of meloxicam: characterization and antiinflammatory activity. Artif Cells Nanomed Biotechnol. 2016 Feb 28:1-8. [Epub ahead of print] PubMed PMID: 26924417. 4: Takami Y, Eguchi S, Tateishi M, Ryu T, Mikagi K, Wada Y, Saitsu H. A randomised controlled trial of meloxicam, a Cox-2 inhibitor, to prevent hepatocellular carcinoma recurrence after initial curative treatment. Hepatol Int. 2016 Feb 4. [Epub ahead of print] PubMed PMID: 26846471. 5: Ianiski FR, Alves CB, Ferreira CF, Rech VC, Savegnago L, Wilhelm EA, Luchese C. Meloxicam-loaded nanocapsules as an alternative to improve memory decline in an Alzheimer's disease model in mice: involvement of Na(+), K(+)-ATPase. Metab Brain Dis. 2016 Feb 27. [Epub ahead of print] PubMed PMID: 26922073.