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MedKoo Cat#: 577099 | Name: Melarsomine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Melarsomine, also known as melaminylthioarsenate, is an arsenic-based anthelmintic, has been shown to induce apoptotic cell death. Melarsomine suppresses canine osteosarcoma cell survival via inhibition of Hedgehog-GLI signaling.

Chemical Structure

Melarsomine
Melarsomine
CAS#128470-15-5 (free base)

Theoretical Analysis

MedKoo Cat#: 577099

Name: Melarsomine

CAS#: 128470-15-5 (free base)

Chemical Formula: C13H21AsN8O2S2

Exact Mass: 460.0445

Molecular Weight: 460.41

Elemental Analysis: C, 33.91; H, 4.60; As, 16.27; N, 24.34; O, 6.95; S, 13.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
89141-50-4 (HCl) 128470-15-5 (free base)
Synonym
Melarsomine; melaminylthioarsenate; RM340;
IUPAC/Chemical Name
bis(2-Aminoethyl) p-((4,6-diamino-s-triazin-2-yl)amino)dithiobenzenearsonite
InChi Key
MGEOLZFMLHYCFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21AsN8S2/c15-5-7-23-14(24-8-6-16)9-1-3-10(4-2-9)19-13-21-11(17)20-12(18)22-13/h1-4H,5-8,15-16H2,(H5,17,18,19,20,21,22)
SMILES Code
NCCS[As](SCCN)c1ccc(Nc2nc(N)nc(N)n2)cc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Melarsomine (melaminylthioarsenate) is an arsenic-based anthelmintic. In the U.S., it is marketed under the trade names Immiticide (Merial) and Diroban (Zoetis), and is approved by the FDA's Center for Veterinary Medicine for the treatment of adult heartworm (Dirofilaria immitis) infection in dogs. It is not approved for treatment in cats, or dogs in late-stage infection.

Preparing Stock Solutions

The following data is based on the product molecular weight 460.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Philp HS, Farrell KS, Li RHL. Case report: Disseminated intravascular coagulation in a dog following treatment with melarsomine for Dirofilaria immitis. Front Vet Sci. 2023 Feb 6;10:1118798. doi: 10.3389/fvets.2023.1118798. PMID: 36814463; PMCID: PMC9939911. 2: Vörös K, Becker Z, Dudás Györki Z, Schulze Gronover B, Szalay F. Ultrasonography of the paralumbar muscles as a new aid during melarsomine treatment in canine heartworm disease. Description and illustration of the method - A preliminary study. Acta Vet Hung. 2022 Nov 17;70(4):263-268. doi: 10.1556/004.2022.00034. PMID: 36422692. 3: Vörös K, Becker Z, Kónya R, Arany-Tóth A, Farkas R. Application of Moxidectin and Ultrasound-Aided Injection of Melarsomine During the American Heartworm Society Recommended Treatment Protocol in Dirofilaria immitis Infected Dogs. Vector Borne Zoonotic Dis. 2022 Jul;22(7):382-390. doi: 10.1089/vbz.2021.0108. Epub 2022 Jun 10. PMID: 35687421. 4: Jacobson LS, DiGangi BA. An Accessible Alternative to Melarsomine: "Moxi- Doxy" for Treatment of Adult Heartworm Infection in Dogs. Front Vet Sci. 2021 Jul 27;8:702018. doi: 10.3389/fvets.2021.702018. PMID: 34386540; PMCID: PMC8353148. 5: Nam A, Kim T, Li Q, Rebhun RB, Youn HY, Seo KW. Melarsomine suppresses canine osteosarcoma cell survival via inhibition of Hedgehog-GLI signaling. J Vet Med Sci. 2019 Dec 18;81(12):1722-1729. doi: 10.1292/jvms.19-0043. Epub 2019 Oct 22. PMID: 31645504; PMCID: PMC6943322. 6: Savadelis MD, Day KM, Bradner JL, Wolstenholme AJ, Dzimianski MT, Moorhead AR. Efficacy and side effects of doxycycline versus minocycline in the three- dose melarsomine canine adulticidal heartworm treatment protocol. Parasit Vectors. 2018 Dec 27;11(1):671. doi: 10.1186/s13071-018-3264-z. PMID: 30587225; PMCID: PMC6307258. 7: Hébert L, Guitton E, Madeline A, Géraud T, Zientara S, Laugier C, Hans A, Büscher P, Cauchard J, Petry S. Melarsomine hydrochloride (Cymelarsan®) fails to cure horses with Trypanosoma equiperdum OVI parasites in their cerebrospinal fluid. Vet Parasitol. 2018 Dec 15;264:47-51. doi: 10.1016/j.vetpar.2018.11.005. Epub 2018 Nov 9. PMID: 30503091. 8: Moore SA, Mariani CL, Van Wettere A, Borst LB. Chronic compressive myelopathy and progressive neurologic signs associated with melarsomine dihydrochloride administration in a dog. J Am Anim Hosp Assoc. 2013 Nov-Dec;49(6):389-93. doi: 10.5326/JAAHA-MS-5911. Epub 2013 Sep 19. PMID: 24051262. 9: Desquesnes M, Kamyingkird K, Vergne T, Sarataphan N, Pranee R, Jittapalapong S. An evaluation of melarsomine hydrochloride efficacy for parasitological cure in experimental infection of dairy cattle with Trypanosoma evansi in Thailand. Parasitology. 2011 Aug;138(9):1134-42. doi: 10.1017/S0031182011000771. Epub 2011 Jul 18. PMID: 21767438. 10: Kramer L, Grandi G, Passeri B, Gianelli P, Genchi M, Dzimianski MT, Supakorndej P, Mansour AM, Supakorndej N, McCall SD, McCall JW. Evaluation of lung pathology in Dirofilaria immitis-experimentally infected dogs treated with doxycycline or a combination of doxycycline and ivermectin before administration of melarsomine dihydrochloride. Vet Parasitol. 2011 Mar 22;176(4):357-60. doi: 10.1016/j.vetpar.2011.01.021. Epub 2011 Jan 19. PMID: 21292403. 11: Tarello W. Leucocytozoon toddi in falcons from Kuwait: epidemiology, clinical signs and response to melarsomine. Parasite. 2006 Jun;13(2):179. PMID: 16800128. 12: Tarello W. Serratospiculosis in falcons from Kuwait: incidence, pathogenicity and treatment with melarsomine and ivermectin. Parasite. 2006 Mar;13(1):59-63. doi: 10.1051/parasite/2006131059. PMID: 16605068. 13: Tarello W. Trypanosoma avium incidence, pathogenicity and response to melarsomine in falcons from Kuwait. Parasite. 2005 Mar;12(1):85-7. doi: 10.1051/parasite/2005121085. PMID: 15828588. 14: Hettlich BF, Ryan K, Bergman RL, Marks SL, Lewis BC, Bahr A, Coates JR, Mansell J, Barton CL. Neurologic complications after melarsomine dihydrochloride treatment for Dirofilaria immitis in three dogs. J Am Vet Med Assoc. 2003 Nov 15;223(10):1456-61, 1434. doi: 10.2460/javma.2003.223.1456. PMID: 14627097. 15: Neiffer DL, Klein EC, Calle PP, Linn M, Terrell SP, Walker RL, Todd D, Vice CC, Marks SK. Mortality associated with melarsomine dihydrochloride administration in two North American river otters (Lontra canadensis) and a red panda (Ailurus fulgens fulgens). J Zoo Wildl Med. 2002 Sep;33(3):242-8. doi: 10.1638/1042-7260(2002)033[0242:MAWMDA]2.0.CO;2. PMID: 12462491. 16: Baneth G, Volansky Z, Anug Y, Favia G, Bain O, Goldstein RE, Harrus S. Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin. Vet Parasitol. 2002 Apr 30;105(2):173-8. doi: 10.1016/s0304-4017(02)00006-7. PMID: 11900931. 17: McTier TL, McCall JW, Dzimianski MT, Raynaud JP, Strickland JE. Use of melarsomine dihydrochloride (RM 340) for adulticidal treatment of dogs with naturally acquired infections of Dirofilaria immitis and for clinical prophylaxis during reexposure for 1 year. Vet Parasitol. 1994 Nov;55(3):221-33. doi: 10.1016/0304-4017(93)00643-D. PMID: 7879380. 18: McCall JW, McTier TL, Dzimianski MT, Raynaud JP, Holmes RA. Clinical prophylactic activity of melarsomine dihydrochloride (RM 340) against Dirofilaria immitis in heartworm-naive beagles exposed to natural infection in three southeastern states. Vet Parasitol. 1994 Nov;55(3):205-19. doi: 10.1016/0304-4017(93)00642-C. PMID: 7879379. 19: Rawlings CA, Raynaud JP, Lewis RE, Duncan JR. Pulmonary thromboembolism and hypertension after thiacetarsamide vs melarsomine dihydrochloride treatment of Dirofilaria immitis infection in dogs. Am J Vet Res. 1993 Jun;54(6):920-5. PMID: 8323063. 20: Raynaud JP. Thiacetarsamide (adulticide) versus melarsomine (RM 340) developed as macrofilaricide (adulticide and larvicide) to cure canine heartworm infection in dogs. Ann Rech Vet. 1992;23(1):1-25. PMID: 1510336.