TPT-260 2HCl, also known as R55, is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP. **** Please also see similar products: TPT-197; TPT-260; TPT-172.
MedKoo Cat#: 504210
Name: TPT-260 2HCl (R55)
CAS#: 2076-91-7 (2HCl)
Chemical Formula: C8H14Cl2N4S3
Exact Mass: 0.0000
Molecular Weight: 333.31
Elemental Analysis: Elemental Analysis: C, 28.83; H, 4.23; Cl, 21.27; N, 16.81; S, 28.86
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 62.5 | 240.02 |
The following data is based on the product molecular weight 333.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
