MedKoo Cat#: 504211 | Name: TPT-172 HCl (R33)
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TPT-172, also known as R33 (described in Mecozzi et al' s paper), is a thiophene thiourea derivative with molecule weight 172 in free base form. There is no formal name yet, we temporally call this molecule as TPT-172. Please also see similar products: TPT-197; TPT-260; TPT-172.

Chemical Structure

TPT-172 HCl (R33)
TPT-172 HCl (R33)
CAS#32415-42-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 504211

Name: TPT-172 HCl (R33)

CAS#: 32415-42-2 (HCl)

Chemical Formula: C6H9ClN2S2

Exact Mass: 207.9896

Molecular Weight: 208.73

Elemental Analysis: C, 34.52; H, 4.35; Cl, 16.98; N, 13.42; S, 30.72

Price and Availability

Size Price Availability Quantity
5mg USD 90.00 Ready to ship
10mg USD 150.00 Ready to ship
25mg USD 250.00 Ready to ship
50mg USD 450.00 Ready to ship
100mg USD 750.00 Ready to ship
200mg USD 1,350.00 Ready to ship
500mg USD 2,650.00 Ready to ship
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Related CAS #
109841-87-4 (free base) 32415-42-2 (HCl)
Synonym
TPT172; TPT-172; TPT 172 HCl; thiophene thiourea derivative. R33
IUPAC/Chemical Name
thiophen-2-ylmethyl carbamimidothioate hydrochloride.
InChi Key
GFYZVDOORWWFNZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H8N2S2.ClH/c7-6(8)10-4-5-2-1-3-9-5;/h1-3H,4H2,(H3,7,8);1H
SMILES Code
NC(SCC1=CC=CS1)=N.[H]Cl
Appearance
white to off-white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO and water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in water
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
N/A
In vitro activity:
N/A
In vivo activity:
N/A
Solvent mg/mL mM
Solubility
Soluble in DMSO and water 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 208.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
N/A
In vitro protocol:
N/A
In vivo protocol:
N/A
1: Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. PubMed PMID: 24747528.