Mefloquine mesylate | CAS# 64003-26-5 | Biochemical

MedKoo Cat#: 577080 | Name: Mefloquine mesylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mefloquine mesylate is a phospholipid-interacting antimalarial drug.

Chemical Structure

Mefloquine mesylate

CAS#64003-26-5 (mesylate)

Theoretical Analysis

MedKoo Cat#: 577080

Name: Mefloquine mesylate

CAS#: 64003-26-5 (mesylate)

Chemical Formula: C18H20F6N2O4S

Exact Mass: 474.1048

Molecular Weight: 474.42

Elemental Analysis: C, 45.57; H, 4.25; F, 24.03; N, 5.90; O, 13.49; S, 6.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

51773-92-3 (HCl) 53230-10-7 (free base) 64003-26-5 (mesylate)

Synonym

Mefloquine mesylate; Mefloquine methanesulfonate

IUPAC/Chemical Name

4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,s*)-(+/-)-, monomethanesulfonate (salt)

InChi Key

GFKKBAFIZVIFAZ-YLCXCWDSSA-N

InChi Code

InChI=1S/C17H16F6N2O.CH4O3S/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;1-5(2,3)4/h3-5,8,12,15,24,26H,1-2,6-7H2;1H3,(H,2,3,4)/t12-,15+;/m1./s1

SMILES Code

CS(=O)(=O)O.O[C@H]([C@H]1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 474.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Goto TE, Caseli L. The interaction of mefloquine hydrochloride with cell membrane models at the air-water interface is modulated by the monolayer lipid composition. J Colloid Interface Sci. 2014 Oct 1;431:24-30. doi: 10.1016/j.jcis.2014.05.050. Epub 2014 Jun 14. PubMed PMID: 24980622. 2: Yadav AV, Dabke AP, Shete AS. Crystal engineering to improve physicochemical properties of mefloquine hydrochloride. Drug Dev Ind Pharm. 2010 Sep;36(9):1036-45. doi: 10.3109/03639041003642065. PubMed PMID: 20334542. 3: Karle JM, Karle IL. Crystal structure of (-)-mefloquine hydrochloride reveals consistency of configuration with biological activity. Antimicrob Agents Chemother. 2002 May;46(5):1529-34. PubMed PMID: 11959592; PubMed Central PMCID: PMC127198. 4: Stockwell JR. Aeromedical considerations of malaria prophylaxis with mefloquine hydrochloride. Aviat Space Environ Med. 1982 Oct;53(10):1011-3. PubMed PMID: 6983345.