MedKoo Cat#: 414504 | Name: Mercurophylline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mercurophylline is a combination of Na salt of mercamphamidum & theophylline formerly used as a diuretic.

Chemical Structure

Mercurophylline
CAS#124-82-3

Theoretical Analysis

MedKoo Cat#: 414504

Name: Mercurophylline

CAS#: 124-82-3

Chemical Formula: C14H22HgNNaO5

Exact Mass: 509.1102

Molecular Weight: 507.91

Elemental Analysis: C, 33.11; H, 4.37; Hg, 39.49; N, 2.76; Na, 4.53; O, 15.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Mercurophylline; Mercuzan; Novurit; Osmuryl; Sodium mercurin
IUPAC/Chemical Name
Mercurate(1-), (3-(((3-carboxylato-2,2,3-trimethylcyclopentyl)carbonyl-kappaO)amino)-2-methoxypropyl-kappaC)hydroxy-, sodium
InChi Key
BOSRWILJSQCVDJ-UHFFFAOYSA-M
InChi Code
InChI=1S/C14H23NO4.Hg.Na.O/c1-9(19-5)8-15-11(16)10-6-7-14(4,12(17)18)13(10,2)3;;;/h1,9-10H,6-8H2,2-5H3,(H,15,16)(H,17,18);;;/q-1;+2;+1;-1/p-1
SMILES Code
COC1CNC(C2CCC(C([O-])=O)(C2(C)C)C)=O[Hg+2]([CH-]1)[O-].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 507.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: LECHNER E, NUNEZ H, NEMIR P Jr, BELLET S. A comparison of the tolerance of the normal dog and the dog with myocardial infarction to an organic mercurial (mercurophylline); a study of the serum and muscle electrolytes. Am J Med Sci. 1954 Sep;228(3):282-7. PMID: 13197378. 2: Szabó G, Serényi P, Magyar Z. The effect of diuretic drugs on lymph flow in experimental ascites. Arzneimittelforschung. 1979;29(3):474-7. PMID: 582731. 3: Janik B, Holiat D. Nowa metoda oznaczania rteci w merkurofilinie [New method of determination of mercury in mercurophylline]. Acta Pol Pharm. 1970;27(2):119-22. Polish. PMID: 5422245. 4: WAIFE SL, PRATT PT. Fatal mercurial poisoning following prolonged administration of mercurophylline. Arch Intern Med (Chic). 1946 Jul;78:42-8. doi: 10.1001/archinte.1946.00220010052005. PMID: 20994318. 5: DE VRIES A. Changes in hemoglobin and total plasma protein after injection of mercurophylline. Arch Intern Med (Chic). 1946 Aug;78:181-96. doi: 10.1001/archinte.1946.00220020059004. PMID: 20997049. 6: RADO J, BLUMENFELD G, BARATH F, SZIROM I. A novurit-refractaer cardialis oedema ACTH kezelése. II. Tubularis tényezók szerepe a hypochloruriában és Hg- resistentiában [ACTH therapy in cardiac edema refractory to novurit. II. Role of tubular factors in hypochloruria and mercury resistance]. Orv Hetil. 1957 Apr 21;98(16):408-13. Hungarian. PMID: 13452490. 7: LEAMON WG Jr. The prolonged use of mercupurin in congestive cardiac failure; report of a case receiving 437 injections over a period of 5 years; autopsy. Proc Am Fed Clin Res. 1945;2:25. PMID: 20275586. 8: FOLDVARY G, FULOP T. Adat a novurit extrarenalis hatásához [Extrarenal effects of novurit]. Orv Hetil. 1958 Mar 16;99(11):385-6. Hungarian. PMID: 13553408. 9: Lebedev AA. Izuchenie mekhanizma deĭstviia diuretikov metodom fliuorestsentnogo zonda [Mechanism of action of diuretics studied by a fluorescent probe method]. Farmakol Toksikol. 1983 Nov-Dec;46(6):79-83. Russian. PMID: 6653766. 10: VEKSLER MI, KSENOFONTOVA MA, LEIMAN SL. [The diuretic effect of novurit]. Sov Med. 1960 Oct;24:82-4. Russian. PMID: 13780622.