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MedKoo Cat#: 414499 | Name: Novenamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Novenamine is the active moiety of novobiocin. It consists of the sugar moiety noviose and the coumarin residue of novobiocin

Chemical Structure

Novenamine
Novenamine
CAS# 31026-09-2

Theoretical Analysis

MedKoo Cat#: 414499

Name: Novenamine

CAS#: 31026-09-2

Chemical Formula: C19H24N2O9

Exact Mass: 424.1482

Molecular Weight: 424.41

Elemental Analysis: C, 53.77; H, 5.70; N, 6.60; O, 33.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Novenamine
IUPAC/Chemical Name
(3R,4S,5R,6R)-6-((3-amino-4-hydroxy-8-methyl-2-oxo-2H-chromen-7-yl)oxy)-5-hydroxy-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate
InChi Key
RXMJJPBQGFPXEP-DUFGSWQCSA-N
InChi Code
InChI=1S/C19H24N2O9/c1-7-9(6-5-8-11(22)10(20)16(24)28-13(7)8)27-17-12(23)14(29-18(21)25)15(26-4)19(2,3)30-17/h5-6,12,14-15,17,22-23H,20H2,1-4H3,(H2,21,25)/t12-,14+,15-,17-/m1/s1
SMILES Code
CO[C@@H]1[C@H]([C@H]([C@@H](OC1(C)C)Oc2c(C)c3c(C(O)=C(C(O3)=O)N)cc2)O)OC(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 424.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Reusser F, Dolak LA. Novenamine is the active moiety in novobiocin. J Antibiot (Tokyo). 1986 Feb;39(2):272-4. PMID: 3007416. 2: Sebek OK, Hoeksema H. Enzymic formation of novenamine, a noviosyl- aminocoumarin moiety of novobiocin. J Antibiot (Tokyo). 1972 Jul;25(7):434-6. doi: 10.7164/antibiotics.25.434. PMID: 4661100. 3: Hooper DC, Wolfson JS, McHugh GL, Swartz MD, Tung C, Swartz MN. Elimination of plasmid pMG110 from Escherichia coli by novobiocin and other inhibitors of DNA gyrase. Antimicrob Agents Chemother. 1984 May;25(5):586-90. doi: 10.1128/AAC.25.5.586. PMID: 6329090; PMCID: PMC185592. 4: Althaus IW, Kézdy FJ, Peterson T, Spilman CH, Reusser F. Novenamines as inhibitors of two independent enzymes during DNA replication in a toluenized Escherichia coli cell system. Biochem Pharmacol. 1996 May 17;51(10):1373-8. doi: 10.1016/0006-2952(96)00061-5. PMID: 8787554. 5: Althaus IW, Franks KM, Langley KB, Kézdy FJ, Peterson T, Buxser SE, Decker DE, Dolak LA, Ulrich RG, Reusser F. The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H. Experientia. 1996 Apr 15;52(4):329-35. doi: 10.1007/BF01919535. PMID: 8620935.