MDL811 is SIRT6 activator. MDL-811 remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and primary mouse microglia, which were abolished by silencing SIRT6. MDL-811-activated SIRT6 directly interacted with enhancer of zeste homolog 2 (EZH2) and promoted deacetylation of EZH2 which could bind to the promoter of Foxc1 and upregulate its expression to modulate inflammation. MDL-811 could be an alternative therapeutic candidate for ischemic stroke and other brain disorders associated with neuroinflammation.
MedKoo Cat#: 464926
Name: MDL811
CAS#: 2275619-98-0 (R-isomer)
Chemical Formula: C25H25BrCl2FN3O5S2
Exact Mass: 678.9780
Molecular Weight: 681.41
Elemental Analysis: C, 44.07; H, 3.70; Br, 11.73; Cl, 10.40; F, 2.79; N, 6.17; O, 11.74; S, 9.41
The following data is based on the product molecular weight 681.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
