VU6005852 | CAS#unknown | M1 receptor PAM

MedKoo Cat#: 464871 | Name: VU6005852

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU6005852 is a positive allosteric modulators of the muscarinic acetylcholine receptor M1. VU6005852 shows robust selectivity for the M1 mAChR, and no M1 agonism.

Chemical Structure

VU6005852

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464871

Name: VU6005852

CAS#: unknown

Chemical Formula: C25H23F2N5O2

Exact Mass: 463.1820

Molecular Weight: 463.49

Elemental Analysis: C, 64.79; H, 5.00; F, 8.20; N, 15.11; O, 6.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VU6005852; VU 6005852; VU-6005852;

IUPAC/Chemical Name

5-(2,6-difluoro-4-(2-methyl-2H-indazol-4-yl)benzyl)-1-((tetrahydrofuran-2-yl)methyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

InChi Key

CWJZFECAZYWCIF-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H23F2N5O2/c1-30-13-19-18(5-2-6-23(19)29-30)15-8-21(26)20(22(27)9-15)14-31-11-16-10-28-32(24(16)25(31)33)12-17-4-3-7-34-17/h2,5-6,8-10,13,17H,3-4,7,11-12,14H2,1H3

SMILES Code

FC1=C(CN2C(C(N(CC3OCCC3)N=C4)=C4C2)=O)C(F)=CC(C5=CC=CC6=NN(C)C=C65)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 463.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Spearing PK, Cho HP, Luscombe VB, Blobaum AL, Boutaud O, Engers DW, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Bender AM. Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1. Bioorg Med Chem Lett. 2021 Jun 9;47:128193. doi: 10.1016/j.bmcl.2021.128193. Epub ahead of print. PMID: 34118412.