MedKoo Cat#: 130346 | Name: (S,R,S)-AHPC-alkyne-piperidine hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(S,R,S)-AHPC-alkyne-piperidine hydrochloride is vital in the synthesis of PROTACs and protein degraders, consisting of a (VHL)-recruiting ligand, a rigid linker, and a pendant amine that reacts with the carboxylic acid on the target ligand.

Chemical Structure

(S,R,S)-AHPC-alkyne-piperidine hydrochloride
(S,R,S)-AHPC-alkyne-piperidine hydrochloride
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130346

Name: (S,R,S)-AHPC-alkyne-piperidine hydrochloride

CAS#: N/A

Chemical Formula: C30H40ClN5O4S

Exact Mass: 601.2490

Molecular Weight: 602.19

Elemental Analysis: C, 59.84; H, 6.70; Cl, 5.89; N, 11.63; O, 10.63; S, 5.32

Price and Availability

Size Price Availability Quantity
50mg USD 875.00 2 Weeks
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Related CAS #
No Data
Synonym
(S,R,S)-AHPC-alkyne-piperidine hydrochloride
IUPAC/Chemical Name
(2S,4R)-1-((S)-3,3-dimethyl-2-(3-(piperidin-4-yl)propiolamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
InChi Key
BLUYAMHRXQYAKB-QVRKWNSCSA-N
InChi Code
InChI=1S/C30H39N5O4S.ClH/c1-19-26(40-18-33-19)22-8-5-21(6-9-22)16-32-28(38)24-15-23(36)17-35(24)29(39)27(30(2,3)4)34-25(37)10-7-20-11-13-31-14-12-20;/h5-6,8-9,18,20,23-24,27,31,36H,11-17H2,1-4H3,(H,32,38)(H,34,37);1H/t23-,24+,27-;/m1./s1
SMILES Code
O=C([C@H]1N(C([C@@H](NC(C#CC2CCNCC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3.[H]Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 602.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL