Synonym
Trolamine; CCRIS606; CCRIS-606; CCRIS 606
IUPAC/Chemical Name
2,2',2''-nitrilotris(ethan-1-ol)
InChi Key
GSEJCLTVZPLZKY-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
149.19
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Trolamine: over-the-counter. Prescrire Int. 2010 Apr;19(106):64. PMID: 20568679.
2: Del Rosso JQ, Bikowski J. Trolamine-containing topical emulsion: clinical applications in dermatology. Cutis. 2008 Mar;81(3):209-14. PMID: 18441842.
3: Rosenthal A, Israilevich R, Moy R. Management of acute radiation dermatitis: A review of the literature and proposal for treatment algorithm. J Am Acad Dermatol. 2019 Aug;81(2):558-567. doi: 10.1016/j.jaad.2019.02.047. Epub 2019 Feb 22. PMID: 30802561.
4: Menêses AG, Reis PEDD, Guerra ENS, Canto GL, Ferreira EB. Use of trolamine to prevent and treat acute radiation dermatitis: a systematic review and meta- analysis. Rev Lat Am Enfermagem. 2018;26:e2929. doi: 10.1590/1518-8345.2035.2929. Epub 2018 May 7. PMID: 29742271; PMCID: PMC5942864.
5: Lu S, Lu A, Paslin D. A Comparison of the Wound Healing Efficacy of Trolamine Emulsion, Manuka Gel, and Polymyxin-Bacitracin Ointment. Adv Skin Wound Care. 2020 Apr;33(4):217-220. doi: 10.1097/01.ASW.0000655468.08618.fc. PMID: 32195725.
6: Aaron K, Cooper TE, Warner L, Burton MJ. Ear drops for the removal of ear wax. Cochrane Database Syst Rev. 2018 Jul 25;7(7):CD012171. doi: 10.1002/14651858.CD012171.pub2. PMID: 30043448; PMCID: PMC6492540.
7: Kim Y, Beck-Broichsitter M, Banga AK. Design and Evaluation of a Poly(Lactide-co-Glycolide)-Based In Situ Film-Forming System for Topical Delivery of Trolamine Salicylate. Pharmaceutics. 2019 Aug 12;11(8):409. doi: 10.3390/pharmaceutics11080409. PMID: 31408990; PMCID: PMC6723844.
8: Algozzine GJ, Stein GH, Doering PL, Araujo OE, Akin KC. Trolamine salicylate cream in osteoarthritis of the knee. JAMA. 1982 Mar 5;247(9):1311-3. PMID: 7038182.
9: Abbas H, Bensadoun RJ. Trolamine emulsion for the prevention of radiation dermatitis in patients with squamous cell carcinoma of the head and neck. Support Care Cancer. 2012 Jan;20(1):185-90. doi: 10.1007/s00520-011-1110-3. Epub 2011 Feb 22. PMID: 21340657.
10: Tran B, Wu JJ, Ratner D, Han G. Topical Scar Treatment Products for Wounds: A Systematic Review. Dermatol Surg. 2020 Dec;46(12):1564-1571. doi: 10.1097/DSS.0000000000002712. PMID: 32932267.
