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MedKoo Cat#: 341270 | Name: Naphthylvinylpyridine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Naphthylvinylpyridine is a biochemical.

Chemical Structure

Naphthylvinylpyridine
Naphthylvinylpyridine
CAS#16375-56-7

Theoretical Analysis

MedKoo Cat#: 341270

Name: Naphthylvinylpyridine

CAS#: 16375-56-7

Chemical Formula: C17H13N

Exact Mass: 231.1048

Molecular Weight: 231.30

Elemental Analysis: C, 88.28; H, 5.67; N, 6.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Naphthylvinylpyridine; Yub 25; Yub-25; Yub25.
IUPAC/Chemical Name
Pyridine, 4-(2-(1-naphthalenyl)ethenyl)-
InChi Key
FLKDRTOVVLNOLV-CMDGGOBGSA-N
InChi Code
InChI=1S/C17H13N/c1-2-7-17-15(4-1)5-3-6-16(17)9-8-14-10-12-18-13-11-14/h1-13H/b9-8+
SMILES Code
C1(/C=C/C2=C3C=CC=CC3=CC=C2)=CC=NC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 231.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamada S, Nojiri Y. [2 + 2] Photodimerization of Naphthylvinylpyridines through Cation-π Interactions in Acidic Solution. Molecules. 2017 Mar 20;22(3). pii: E491. doi: 10.3390/molecules22030491. PubMed PMID: 28335523. 2: Obaid AL, Loew LM, Wuskell JP, Salzberg BM. Novel naphthylstyryl-pyridium potentiometric dyes offer advantages for neural network analysis. J Neurosci Methods. 2004 Apr 30;134(2):179-90. PubMed PMID: 15003384. 3: Alcalde E, Barat A, Goya P, Martinez A, Ramirez G, Roca T, Rozas I. Molecular modeling of (E)-1-alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase. Bioorg Med Chem. 1997 May;5(5):949-54. PubMed PMID: 9208104. 4: Fitzgerald RS, Shirahata M, Ishizawa Y. The presynaptic component of a cholinergic mechanism in the carotid body chemotransduction of hypoxia in the cat. Adv Exp Med Biol. 1996;410:245-52. PubMed PMID: 9030306. 5: Kontoyianni M, McGaughey GB, Stewart EL, Cavallito CJ, Bowen JP. Molecular modeling studies of some choline acetyltransferase inhibitors. J Med Chem. 1994 Sep 16;37(19):3128-31. PubMed PMID: 7932536. 6: Henderson TR, Gray AP, Platz RD, Kellar KJ, Dretchen KL. Inhibition of brain choline acetyltransferase in vivo: (E)-1-methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine hydrochloride (B115), a depot form of a potent inhibitor. Toxicol Appl Pharmacol. 1991 Feb;107(2):336-43. PubMed PMID: 1994515. 7: Hamel E, Assumel Lurdin C, Fage D, Edvinsson L, MacKenzie ET. Small pial vessels, but not choroid plexus, exhibit specific biochemical correlates of functional cholinergic innervation. Brain Res. 1990 May 21;516(2):301-9. PubMed PMID: 2364295. 8: Rylett RJ. Synaptosomal "membrane-bound" choline acetyltransferase is most sensitive to inhibition by choline mustard. J Neurochem. 1989 Mar;52(3):869-75. PubMed PMID: 2918313. 9: Carroll PT, Ivy MT. Effect of 2-(4-phenylpiperidino)cyclohexanol (AH 5183) on the veratridine-induced increase in acetylcholine synthesis by rat hippocampal tissue. J Neurochem. 1988 Sep;51(3):808-19. PubMed PMID: 3411328. 10: Carmeliet P, Denef C. Immunocytochemical and pharmacological evidence for an intrinsic cholinomimetic system modulating prolactin and growth hormone release in rat pituitary. Endocrinology. 1988 Aug;123(2):1128-39. PubMed PMID: 3293981. 11: Arnerić SP, Honig MA, Milner TA, Greco S, Iadecola C, Reis DJ. Neuronal and endothelial sites of acetylcholine synthesis and release associated with microvessels in rat cerebral cortex: ultrastructural and neurochemical studies. Brain Res. 1988 Jun 28;454(1-2):11-30. PubMed PMID: 3408997. 12: Gray AP, Platz RD, Henderson TR, Chang TC, Takahashi K, Dretchen KL. Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes. J Med Chem. 1988 Apr;31(4):807-14. PubMed PMID: 3351860. 13: Molinengo L, Orsetti M. Acetylcholine levels in the spinal cord after atropine, diisopropylfluorophosphate and naphthylvinylpyridine. Arch Int Pharmacodyn Ther. 1987 Sep;289(1):18-24. PubMed PMID: 3435202. 14: Carroll PT, Badamchian M, Craig P, Lyness WH. Veratridine-induced breakdown of cytosolic acetylcholine in rat hippocampal minces: an intraterminal form of acetylcholinesterase or choline O-acetyltransferase? Brain Res. 1986 Sep 24;383(1-2):83-99. PubMed PMID: 3768708. 15: Budai D, Rícný J, Kása P, Tucek S. 4-(1-Naphthylvinyl)pyridine decreases brain acetylcholine in vivo, but does not alter the level of acetyl-CoA. J Neurochem. 1986 Mar;46(3):990-2. PubMed PMID: 3950616. 16: Leblanc G, Landis S. Development of choline acetyltransferase (CAT) in the sympathetic innervation of rat sweat glands. J Neurosci. 1986 Jan;6(1):260-5. PubMed PMID: 3080552. 17: Thomas WE. Synthesis of acetylcholine and gamma-aminobutyric acid by dissociated cerebral cortical cells in vitro. Brain Res. 1985 Apr 15;332(1):79-89. PubMed PMID: 2859908. 18: Chweh AY, DeBernardis JF, Siuda JF, Rondan NG, Abola JE, Abraham DJ. Structural correlations of choline acetyltransferase inhibitors: trans-N-(carboxymethyl)-4-(beta-1-naphthylvinyl)pyridinium bromide and cis-N-(2-aminoethyl)-4-(beta-1-naphthylvinyl)-3-methylpyridinium bromide hydrobromide. J Med Chem. 1984 Jul;27(7):825-30. PubMed PMID: 6737426. 19: Benishin CG, Carroll PT. Multiple forms of choline-O-acetyltransferase in mouse and rat brain: solubilization and characterization. J Neurochem. 1983 Oct;41(4):1030-9. PubMed PMID: 6619842. 20: Cozzari C, Hartman BK. Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase. Anal Biochem. 1983 Aug;133(1):120-5. PubMed PMID: 6638474.

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