The right-hand-side labeled ligand [11C]-CHDI-180R is a suitable PET tracer for imaging of mHTT aggregates. [11C]-CHDI-180R is now being advanced to human trials as a first-in-class HD PET radiotracer. CHDI-180R is a first-in-class high-affinity PET imaging ligand specific for mHTT aggregates. Mutant huntingtin (mHTT) protein carrying the elongated N-terminal polyglutamine (polyQ) tract misfolds and forms protein aggregates characteristic of Huntington’s disease (HD) pathology. A high-affinity ligand specific for mHTT aggregates could serve as a positron emission tomography (PET) imaging biomarker for HD therapeutic development and disease progression.
MedKoo Cat#: 556007
Name: CHDI-180R
CAS#: 1883792-80-0
Chemical Formula: C19H16N4O4
Exact Mass: 364.1172
Molecular Weight: 364.36
Elemental Analysis: C, 62.63; H, 4.43; N, 15.38; O, 17.56
The following data is based on the product molecular weight 364.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
