Tezacitabine | CAS# 171176-43-5 | Biochemical

MedKoo Cat#: 576991 | Name: Tezacitabine hydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tezacitabine is an antineoplastic agent.

Chemical Structure

Tezacitabine hydrate

CAS#171176-43-5 (H2O)

Theoretical Analysis

MedKoo Cat#: 576991

Name: Tezacitabine hydrate

CAS#: 171176-43-5 (H2O)

Chemical Formula: C10H14FN3O5

Exact Mass: 275.0917

Molecular Weight: 275.24

Elemental Analysis: C, 43.64; H, 5.13; F, 6.90; N, 15.27; O, 29.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

130306-02-4 (free base) 171176-43-5 (H2O) 153586-81-3 (HCl)

Synonym

FMdC; MDL 101731; MDL101731; MDL-101731; Tezacitabine

IUPAC/Chemical Name

4-amino-1-((2R,4S,5R,E)-3-(fluoromethylene)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrate

InChi Key

XPYQFIISZQCINN-QVXDJYSKSA-N

InChi Code

InChI=1S/C10H12FN3O4.H2O/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17;/h1-3,6,8-9,15-16H,4H2,(H2,12,13,17);1H2/b5-3+;/t6-,8+,9-;/m1./s1

SMILES Code

O.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)/C/2=C\F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 275.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Taverna P, Rendahl K, Jekic-McMullen D, Shao Y, Aardalen K, Salangsang F, Doyle L, Moler E, Hibner B. Tezacitabine enhances the DNA-directed effects of fluoropyrimidines in human colon cancer cells and tumor xenografts. Biochem Pharmacol. 2007 Jan 1;73(1):44-55. doi: 10.1016/j.bcp.2006.09.009. Epub 2006 Sep 16. PMID: 17046720. 2. Skierski JS, Koronkiewicz M, Grieb P. Tezacitabine blocks tumor cells in G1 and S phases of the cell cycle and induces apoptotic cell death. Acta Pol Pharm. 2005 May-Jun;62(3):195-205. PMID: 16193812. 3. Stachnik K, Grieb P, Skierski JS. Cytotoxic effects of cladribine and tezacitabine toward HL-60. Acta Biochim Pol. 2005;52(2):561-5. Epub 2005 May 31. PMID: 15933759.