Indoxyl Sulfate-d5 | CAS#1644451-34-2 | Indoxyl sulfate internal standard

MedKoo Cat#: 464833 | Name: Indoxyl Sulfate-d5 potassium salt

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.

Chemical Structure

Indoxyl Sulfate-d5 potassium salt

CAS#1644451-34-2 (potassium)

Theoretical Analysis

MedKoo Cat#: 464833

Name: Indoxyl Sulfate-d5 potassium salt

CAS#: 1644451-34-2 (potassium)

Chemical Formula: C8HD5KNO4S

Exact Mass: 255.9968

Molecular Weight: 256.33

Elemental Analysis: C, 37.49; H, 4.32; K, 15.25; N, 5.46; O, 24.97; S, 12.51

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 300.00	2 Weeks
5mg	USD 800.00	2 Weeks

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Related CAS #

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Synonym

Indoxyl Sulfate-d5 potassium salt; Indoxyl Sulfate d5 potassium salt;

IUPAC/Chemical Name

potassium 1H-indol-3-yl-2,4,5,6,7-d5 sulfate

InChi Key

MDAWATNFDJIBBD-GWVWGMRQSA-M

InChi Code

InChI=1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8;/h1-5,9H,(H,10,11,12);/q;+1/p-1/i1D,2D,3D,4D,5D;

SMILES Code

[O-]S(OC1=C(NC2=C(C([2H])=C(C([2H])=C21)[2H])[2H])[2H])(=O)=O.[K+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 256.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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