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MedKoo Cat#: 414387 | Name: Niferidil HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Niferidil HCl is a class III antiarrhythmic drug.

Chemical Structure

Niferidil HCl
CAS#1276021-10-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 414387

Name: Niferidil HCl

CAS#: 1276021-10-3 (HCl)

Chemical Formula: C22H27ClFN3O3

Exact Mass:

Molecular Weight: 435.92

Elemental Analysis: C, 60.62; H, 6.24; Cl, 8.13; F, 4.36; N, 9.64; O, 11.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1276021-10-3 (HCl) 1276186-19-6 (free base)
Synonym
Niferidil hydrochloride; Niferidil HCl; Cavutilide hydrochloride
IUPAC/Chemical Name
Benzamide, N-(2-(1-ethyl-4-piperidinyl)-1-(4-fluorophenyl)ethyl)-4-nitro-, hydrochloride
InChi Key
BAIPQSYTPAIAHY-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H26FN3O3.ClH/c1-2-25-13-11-16(12-14-25)15-21(17-3-7-19(23)8-4-17)24-22(27)18-5-9-20(10-6-18)26(28)29;/h3-10,16,21H,2,11-15H2,1H3,(H,24,27);1H
SMILES Code
O=C(NC(C1=CC=C(F)C=C1)CC2CCN(CC)CC2)C3=CC=C([N+]([O-])=O)C=C3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 435.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abramochkin DV, Kuzmin VS, Rosenshtraukh LV. A New Class III Antiarrhythmic Drug Niferidil Prolongs Action Potentials in Guinea Pig Atrial Myocardium via Inhibition of Rapid Delayed Rectifier. Cardiovasc Drugs Ther. 2017 Dec;31(5-6):525-533. doi: 10.1007/s10557-017-6762-x. PMID: 29181609. 2: Maykov EB, Yuricheva YA, Mironov NY, Sokolov SF, Golitsyn SP, Rosenshtraukh LV, Chazov EI. Efficacy of a new class III drug niferidil in cardioversion of persistent atrial fibrillation and flutter. J Cardiovasc Pharmacol. 2014 Sep;64(3):247-55. doi: 10.1097/FJC.0000000000000112. PMID: 24785342. 3: Abramochkin DV, Kuzmin VS, Rosenshtraukh LV. Effects of new class III antiarrhythmic drug niferidil on electrical activity in murine ventricular myocardium and their ionic mechanisms. Naunyn Schmiedebergs Arch Pharmacol. 2015 Oct;388(10):1105-12. doi: 10.1007/s00210-015-1146-x. Epub 2015 Jun 24. PMID: 26105002. 4: Maykov EB, Yuricheva YA, Mironov NY, Sokolov SF, Golitsyn SP, Rozenshtraukh LV, Chazov EI. [Refralon (niferidil) is a new class III antiarrhythmic agent for pharmacological cardioversion for persistent atrial fibrillation and atrial flutter]. Ter Arkh. 2015;87(1):38-48. Russian. doi: 10.17116/terarkh201587138-48. PMID: 25823268. 5: Mironov NIu, Golitsyn SP, Sokolov SF, Maĭkov EB, Shlevkov NB, Iuricheva IuA, Mareev IuV, Rosenshtraukh LV, Chazov EI. [Electrophysiological effects and antiarrhythmic activity of novel domestic class III antiarrhythmogenic drug niferidil administered in patients with paroxismal supraventricular tachycardia]. Eksp Klin Farmakol. 2012;75(10):16-21. Russian. PMID: 23240154. 6: Iuricheva IuA, Maĭkov EB, Sokolov SF, Klimenko IuL, Kratskina TL, Tarasovskiĭ GS, Bil'dinov OA, Bakalov SA, Golitsyn SP, Beloshapko GG, Iushmanova AV, Rozenshtraukh LV, Chazov EI. [First experience of clinical use of new class III antiarrhythmic agent niferidil in patients with persistent atrial fibrillation and flutter]. Kardiologiia. 2011;51(1):55-64. Russian. PMID: 21626804. 7: Maĭkov EB. [New class III antiarrhythmic drugs for treatment of atrial fibrillation]. Kardiologiia. 2012;52(11):56-65. Russian. PMID: 23237397. 8: Egorov IuV, Stolbova VI, Kuz'min VS, Rozenshtraukh LV. [Influence of new III class antiarrhythmic drug Niferidil (RG-2) on bioelectrical activity of rat pulmonary veins myocardium]. Kardiologiia. 2012;52(2):47-51. Russian. PMID: 22792739. 9: Maĭkov EB, Iuricheva IuA, Mironov NIu, Sokolov SF, Golitsyn SP, Rozenshtraukh LV, Chazov EI. [Novel class III antiarrhythmic agent niferidile: review of experimental and clinical studies]. Kardiologiia. 2014;54(1):4-19. Russian. doi: 10.18565/cardio.2014.1.4-19. PMID: 24881306.