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MedKoo Cat#: 414343 | Name: Neticonazole Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neticonazole Free Base is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is only approved for use in Japan. It is sold as a topical ointment under the tradename Atolant.

Chemical Structure

Neticonazole Free Base
Neticonazole Free Base
CAS#130726-68-0 (free base)

Theoretical Analysis

MedKoo Cat#: 414343

Name: Neticonazole Free Base

CAS#: 130726-68-0 (free base)

Chemical Formula: C17H22N2OS

Exact Mass: 302.1453

Molecular Weight: 302.44

Elemental Analysis: C, 67.51; H, 7.33; N, 9.26; O, 5.29; S, 10.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
130773-02-3 (HCl) 130726-68-0 (free base)
Synonym
Neticonazole Free Base; Neticonazol; Neticonazolum
IUPAC/Chemical Name
(E)-1-(2-(Methylthio)-1-(o-(pentyloxy)phenyl)vinyl)imidazole
InChi Key
VWOIKFDZQQLJBJ-DTQAZKPQSA-N
InChi Code
InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+
SMILES Code
CCCCCOC1=CC=CC=C1/C(N2C=CN=C2)=C\SC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 302.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gu L, Xu Y, Xu W, Li M, Su H, Li C, Liu Z. The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer. Invest New Drugs. 2020 Apr;38(2):221-228. doi: 10.1007/s10637-019-00759-7. Epub 2019 Mar 19. PMID: 30887254. 2: Datta A, Kim H, McGee L, Johnson AE, Talwar S, Marugan J, Southall N, Hu X, Lal M, Mondal D, Ferrer M, Abdel-Mageed AB. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161. doi: 10.1038/s41598-018-26411-7. PMID: 29802284; PMCID: PMC5970137. 3: Tsuboi R, Matsumoto T, Ogawa H. Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group. Int J Dermatol. 1996 May;35(5):371-3. doi: 10.1111/j.1365-4362.1996.tb03644.x. PMID: 8734665. 4: Matsuki M, Kanatsu H, Watanabe T, Ogasawara A, Mikami T, Matsumoto T. Effects of antifungal drugs on proliferation signals in Candida albicans. Biol Pharm Bull. 2006 May;29(5):919-22. doi: 10.1248/bpb.29.919. PMID: 16651719. 5: Lynch C, Mackowiak B, Huang R, Li L, Heyward S, Sakamuru S, Wang H, Xia M. Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library. Toxicol Sci. 2019 Jan 1;167(1):282-292. doi: 10.1093/toxsci/kfy242. PMID: 30247703; PMCID: PMC6657574. 6: Ishizaki S, Watanabe S, Sawada M, Ninomiya J, Otani T, Tanaka M, Harada T, Kamei K. A Case of Tinea Pedis in a Child Caused by Trichophyton interdigitale with Two Different Colony Phenotypes on Primary Culture. Med Mycol J. 2019;60(4):91-94. doi: 10.3314/mmj.19-00011. PMID: 31787732. 7: Koga H, Nanjoh Y, Makimura K, Tsuboi R. In vitro antifungal activities of luliconazole, a new topical imidazole. Med Mycol. 2009;47(6):640-7. doi: 10.1080/13693780802541518. PMID: 19115136. 8: Tatsumi Y, Yokoo M, Arika T, Yamaguchi H. In vivo fungicidal effect of KP-103 in a guinea pig model of interdigital tinea pedis determined by using a new method for removing the antimycotic carryover effect. Microbiol Immunol. 2002;46(7):433-9. doi: 10.1111/j.1348-0421.2002.tb02717.x. PMID: 12222929. 9: Katoh T. [Guidelines for diagnosis and treatment of mucocutaneous candidiasis]. Nihon Ishinkin Gakkai Zasshi. 2009;50(4):207-12. Japanese. doi: 10.3314/jjmm.50.207. PMID: 19942790. 10: Maebashi K, Itoyama T, Uchida K, Yamaguchi H, Asaoka T, Iwasa A. [Therapeutic efficacies of neticonazole (SS717) cream and solution in experimental cutaneous Candida albicans infection of guinea pigs]. Jpn J Antibiot. 1993 Oct;46(10):896-903. Japanese. PMID: 8254891.