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MedKoo Cat#: 414295 | Name: Nco 700

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nco 700 is a synthetic inhibitor of calcium-activated protease.

Chemical Structure

Nco 700
Nco 700
CAS#84579-82-8

Theoretical Analysis

MedKoo Cat#: 414295

Name: Nco 700

CAS#: 84579-82-8

Chemical Formula: C52H80N6O20S

Exact Mass: 1140.5148

Molecular Weight: 1141.29

Elemental Analysis: C, 54.72; H, 7.07; N, 7.36; O, 28.04; S, 2.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Nco 700; Nco700; Nco-700
IUPAC/Chemical Name
Oxiranecarboxylic acid, 3-(((3-methyl-1-((4-((2,3,4-trimethoxyphenyl)methyl)-1-piperazinyl)carbonyl)butyl)amino)carbonyl)-, ethyl ester, (2R-(2-alpha,3-beta(S*)))-, sulfate (2:1)
InChi Key
AWNIEFSZNNQBRL-ZCNUETMSSA-N
InChi Code
InChI=1S/2C26H39N3O8.H2O4S/c2*1-7-36-26(32)23-22(37-23)24(30)27-18(14-16(2)3)25(31)29-12-10-28(11-13-29)15-17-8-9-19(33-4)21(35-6)20(17)34-5;1-5(2,3)4/h2*8-9,16,18,22-23H,7,10-15H2,1-6H3,(H,27,30);(H2,1,2,3,4)/t2*18?,22-,23-;/m11./s1
SMILES Code
O=C([C@H]1[C@H](C(OCC)=O)O1)NC(C(N2CCN(CC3=CC=C(OC)C(OC)=C3OC)CC2)=O)CC(C)C.O=C([C@H]4[C@H](C(OCC)=O)O4)NC(C(N5CCN(CC6=CC=C(OC)C(OC)=C6OC)CC5)=O)CC(C)C.O=S(O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,141.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sashida H, Abiko Y. Inhibition with NCO-700, a protease inhibitor, of degradation of cardiac myofibrillar proteins during ischemia in dogs. Biochem Pharmacol. 1985 Nov 1;34(21):3875-80. doi: 10.1016/0006-2952(85)90437-x. PMID: 4062961. 2: Haga N, Ishibashi T, Hara A, Abiko Y. Effect of NCO-700, an inhibitor of protease, on myocardial pH decreased by coronary occlusion in dogs. Pharmacology. 1985;31(4):208-17. doi: 10.1159/000138117. PMID: 4059326. 3: Eilon GF, Gu J, Slater LM, Hara K, Jacobs JW. Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents. Cancer Chemother Pharmacol. 2000;45(3):183-91. doi: 10.1007/s002800050028. PMID: 10663635. 4: Ikeda H, Oda T, Kuwano K, Nakayama H, Ueno T, Koga Y, Toshima H. A protease inhibitor, NCO-700, improves the contractile function in stunned canine myocardium. Jpn Circ J. 1994 Sep;58(9):713-9. doi: 10.1253/jcj.58.713. PMID: 7967015. 5: Tawara K, Fujisawa S, Nakai K. Effect of NCO-700, an inhibitor of thiol protease, on reactive oxygen production by chemotactic peptide-stimulated rabbit peripheral granulocytes. Experientia. 1988 Apr 15;44(4):346-7. doi: 10.1007/BF01961277. PMID: 2834217. 6: Ichihara K, Hayase N, Chiba K, Parvez H, Abiko Y. Effect of NCO-700, an inhibitor of protease, on lysosomal rupture in the ischemic myocardium. J Pharm Sci. 1991 Mar;80(3):252-4. doi: 10.1002/jps.2600800312. PMID: 2051342. 7: Toyo-oka T, Kamishiro T, Masaki M, Masaki T. Reduction of experimentally produced acute myocardial infarction size by a new synthetic inhibitor, NCO-700, against calcium-activated neutral protease. Jpn Heart J. 1982 Sep;23(5):829-34. doi: 10.1536/ihj.23.829. PMID: 6294370. 8: Shibata T, Yamamoto F, Suehiro S, Kinoshita H. Effects of protease inhibitors on postischemic recovery of the heart. Cardiovasc Drugs Ther. 1997 Sep;11(4):547-56. doi: 10.1023/a:1007723417775. PMID: 9358959. 9: Sata N, Klonowski-Stumpe H, Han B, Häussinger D, Niederau C. Menadione induces both necrosis and apoptosis in rat pancreatic acinar AR4-2J cells. Free Radic Biol Med. 1997;23(6):844-50. doi: 10.1016/s0891-5849(97)00064-6. PMID: 9378363. 10: Carrasco-Marín E, Paz-Miguel JE, López-Mato P, Alvarez-Domínguez C, Leyva- Cobián F. Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells. Immunology. 1998 Nov;95(3):314-21. doi: 10.1046/j.1365-2567.1998.00618.x. PMID: 9824492; PMCID: PMC1364395.

View History

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