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MedKoo Cat#: 414279 | Name: PD 124966
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD 124966 is a potent antitumor agent isolated from Streptomyces sp.; a cyclic hexadepsipeptide; antagonist of complement 5A.

Chemical Structure

PD 124966
PD 124966
CAS#125228-51-5

Theoretical Analysis

MedKoo Cat#: 414279

Name: PD 124966

CAS#: 125228-51-5

Chemical Formula: C38H64N8O13

Exact Mass: 840.4593

Molecular Weight: 840.95

Elemental Analysis: C, 54.27; H, 7.67; N, 13.32; O, 24.73

Price and Availability

Size Price Availability Quantity
500µg USD 355.00 2 Weeks
2.5mg USD 903.00 2 Weeks
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Related CAS #
No Data
Synonym
PD 124966; PD124966; PD-124966; L 156602; L156602; L-156602
IUPAC/Chemical Name
N-(6,18-dihydroxy-22-isopropyl-7,19-dimethyl-5,8,11,17,20,24-hexaoxodocosahydro-13H,22H-dipyridazino[6,1-f:6',1'-o][1]oxa[4,7,10,13,16]pentaazacyclononadecin-23-yl)-2-hydroxy-2-(2-hydroxy-6-methyl-5-(2-methylbutyl)tetrahydro-2H-pyran-2-yl)propanamide
InChi Key
ZJZOPNINWIGNQW-UHFFFAOYSA-N
InChi Code
InChI=1S/C38H64N8O13/c1-9-21(4)18-25-14-15-38(55,59-24(25)7)37(8,54)36(53)42-29-30(20(2)3)58-35(52)23(6)46(57)32(49)26-12-10-16-40-43(26)28(47)19-39-31(48)22(5)45(56)33(50)27-13-11-17-41-44(27)34(29)51/h20-27,29-30,40-41,54-57H,9-19H2,1-8H3,(H,39,48)(H,42,53)
SMILES Code
CCC(CC1CCC(OC1C)(C(O)(C(NC2C(C(C)C)OC(C(N(C(C3CCCNN3C(CNC(C(N(C(C4CCCNN4C2=O)=O)O)C)=O)=O)=O)O)C)=O)=O)C)O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PD 124966 is a potent antitumor agent isolated from Streptomyces sp.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 840.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Hashizume H, Harada S, Sawa R, Iijima K, Kubota Y, Shibuya Y, Nagasaka R, Hatano M, Igarashi M. New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602. J Antibiot (Tokyo). 2021 Jan;74(1):80-85. doi: 10.1038/s41429-020-0361-y. Epub 2020 Aug 14. PMID: 32796954. 2: Hurley TR, Bunge RH, Willmer NE, Hokanson GC, French JC. PD 124,895 and PD 124,966, two new antitumor antibiotics. J Antibiot (Tokyo). 1986 Dec;39(12):1651-6. doi: 10.7164/antibiotics.39.1651. PMID: 3818438. 3: Hensens OD, Borris RP, Koupal LR, Caldwell CG, Currie SA, Haidri AA, Homnick CF, Honeycutt SS, Lindenmayer SM, Schwartz CD, et al. L-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from Streptomyces sp. MA6348. Fermentation, isolation and structure determination. J Antibiot (Tokyo). 1991 Feb;44(2):249-54. doi: 10.7164/antibiotics.44.249. PMID: 2010362. 4: Tsuji RF, Yamakoshi J, Uramoto M, Koshino H, Saito M, Kikuchi M, Masuda T. Anti-inflammatory effects and specificity of L-156,602: comparison of effects on concanavalin A and zymosan-induced footpad edema, and contact sensitivity response. Immunopharmacology. 1995 Feb;29(1):79-87. doi: 10.1016/0162-3109(95)00047-w. PMID: 7768675. 5: Tsuji RF, Uramoto M, Koshino H, Tsuji NM, Magae J, Nagai K, Yamasaki M. Preferential suppression of delayed-type hypersensitivity by L-156,602, a C5a receptor antagonist. Biosci Biotechnol Biochem. 1992 Oct;56(10):1686-9. doi: 10.1271/bbb.56.1686. PMID: 1369067. 6: Tsuji RF, Magae J, Nagai K, Yamasaki M. Effects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation. Biosci Biotechnol Biochem. 1992 Dec;56(12):2034-6. doi: 10.1271/bbb.56.2034. PMID: 1369097.

View History

AVN-211

AVN-211

MB3212

MB3212

DPI-287

DPI-287

EINECS 303-060-9

EINECS 303-060-9

Eipw 103

Eipw 103

Ektomin

Ektomin