P7C3-A20 | CAS#1235481-90-9 | 1485572-67-5 | neuroprotective agent

MedKoo Cat#: 510283 | Name: P7C3-A20

Description:

WARNING: This product is for research use only, not for human or veterinary use.

P7C3-A20 is an analogue of P7C3, a NAMPT activator, and is a proneurogenic, neuroprotective agent. P7C3-A20 displayed increased activity and an improved toxicity profile compared to P7C3. P7C3-A20 demonstrated greater proneurogenic efficacy than a wide spectrum of currently marketed antidepressant drugs. P7C3-A20 showed neuroprotective properties in rodent models of Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury and age-related cognitive decline.

Chemical Structure

P7C3-A20

CAS#1235481-90-9 (free base)

Theoretical Analysis

MedKoo Cat#: 510283

Name: P7C3-A20

CAS#: 1235481-90-9 (free base)

Chemical Formula: C22H19Br2FN2O

Exact Mass: 503.9848

Molecular Weight: 506.21

Elemental Analysis: C, 52.20; H, 3.78; Br, 31.57; F, 3.75; N, 5.53; O, 3.16

Price and Availability

Size	Price	Availability
10mg	USD 90.00	Ready to ship
25mg	USD 150.00	Ready to ship
50mg	USD 250.00	Ready to ship
100mg	USD 450.00	Ready to ship
200mg	USD 750.00	Ready to ship
500mg	USD 1,650.00	Ready to ship
1g	USD 2,950.00	Ready to ship
2g	USD 5,250.00	Ready to ship

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Related CAS #

1235481-90-9 (free base) 1485572-67-5 (HCl)

Synonym

P7C3-A20; P7C3A20; P7C3 A20

IUPAC/Chemical Name

N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline

InChi Key

XNLTWMQBJFWQOU-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H19Br2FN2O/c1-28-18-4-2-3-17(11-18)26-12-16(25)13-27-21-7-5-14(23)9-19(21)20-10-15(24)6-8-22(20)27/h2-11,16,26H,12-13H2,1H3

SMILES Code

COC1=CC(NCC(F)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3)=CC=C1

Appearance

Light yellow solid to semi-solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

1. Literature method: P7C3A20 were dissolved in 5% dextrose (pH 7.0) with 2.5% DMSO and 10% Cremaphor EL (Sigma; C5135). (Ref: Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5). 2. This drug may be formulated in DMSO 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# CAS#1235481-90-9 (P7C3-A20 free); CAS#1485572-67-5 (P7C3-A20 HCl salt)

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#BBC51106

View CoA: current batch, Lot#A9T07K25

QC Data

View QC data: current batch, Lot#A9T07K25

View QC data: current batch, Lot#BBC51106

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment

In vitro activity:

The aim of this study was to investigate the effect of a potential NAMPT activator, P7C3-A20, an aminopropyl carbazole derivative, on ischemic stroke. In vitro study, neuron protection effect of P7C3-A20 was investigated by co-incubation with primary neurons subjected to oxygen-glucose deprivation (OGD) or oxygen-glucose deprivation/reperfusion (OGD/R) injury. In order to explore the role of P7C3‐A20 in cerebral ischemia, we cultured primary cortical neurons and established neuronal OGD model to mimic in vitro ischemic stress. Primary cortical neurons were exposed to OGD condition for 1.5 and 12 h, respectively. We found that neuronal injuries were growing worse following prolonged duration of OGD. Prolonged administration of P7C3‐A20 may have positive effects for the recovery of chronic stroke. Furthermore, P7C3‐A20 may benefit poststroke recovery because of its role in neurogenesis, given evidence that P7C3‐A20 could rescue NPAS3−/−‐induced loss of hippocampal neurogenesis, and augment hippocampal neurogenesis. CNS Neurosci Ther. 2016 Sep; 22(9): 782–788. Published online 2016 Jun 23. doi: 10.1111/cns.12576 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492790/

In vivo activity:

This laboratory model produces neurodegeneration and neurobehavioral deficits reminiscent of TBI in people. Mice were treated and analyzed beginning 1 y after a single injury, as outlined in Fig. 1A. Two-month-old mice were subjected to TBI or sham-TBI and housed under standard conditions for 1 y. Mice were then administered either vehicle (TBI-Veh, Sham-Veh) or P7C3-A20 (10 mg⋅kg−1⋅day−1 intraperitoneally [IP]; TBI-P7C3-A20) for 4 wk. Animals were then housed under standard conditions with no treatment for four additional months (Fig. 1A). At 19 mo of age (17 mo postinjury), TBI-Veh mice exhibited impaired learning (Fig. 1B) and memory (Fig. 1C) whereas TBI-P7C3-A20 mice again performed as well as Sham-Veh animals. P7C3-A20 directly protects brain microvascular endothelial cells in vivo in mice and in cultured human cells. Taken together, the results suggest that BBB deterioration may be a major contributor to chronic neurodegeneration after remote TBI and that its repair may halt this pathology. Proc Natl Acad Sci U S A. 2020 Nov 3; 117(44): 27667–27675. Published online 2020 Oct 21. doi: 10.1073/pnas.2010430117 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959512/

	Solvent	mg/mL	mM
Solubility
	DMSO	5.1	10.10

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 506.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Vázquez-Rosa E, Shin MK, Dhar M, Chaubey K, Cintrón-Pérez CJ, Tang X, Liao X, Miller E, Koh Y, Barker S, Franke K, Crosby DR, Schroeder R, Emery J, Yin TC, Fujioka H, Reynolds JD, Harper MM, Jain MK, Pieper AA. P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27667-27675. doi: 10.1073/pnas.2010430117. Epub 2020 Oct 21. PMID: 33087571; PMCID: PMC7959512. 2. Hill CS, Menon DK, Coleman MP. P7C3-A20 neuroprotection is independent of Wallerian degeneration in primary neuronal culture. Neuroreport. 2018 Dec 12;29(18):1544-1549. doi: 10.1097/WNR.0000000000001146. PMID: 30334859; PMCID: PMC6250284. 3.Wang SN, Xu TY, Wang X, Guan YF, Zhang SL, Wang P, Miao CY. Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke. CNS Neurosci Ther. 2016 Sep;22(9):782-8. doi: 10.1111/cns.12576. Epub 2016 Jun 23. PMID: 27333812; PMCID: PMC6492790.

In vitro protocol:

1.Wang SN, Xu TY, Wang X, Guan YF, Zhang SL, Wang P, Miao CY. Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke. CNS Neurosci Ther. 2016 Sep;22(9):782-8. doi: 10.1111/cns.12576. Epub 2016 Jun 23. PMID: 27333812; PMCID: PMC6492790.

In vivo protocol:

1: Iwatani Y, Hayashi H, Oba H, Oba M, Sawamura A, Moriyama Y, Takagi N. Possible involvement of NAMPT in neuronal survival in cerebral ischemic injury under high-glucose conditions through the FoxO3a/LC3 pathway. Biomed Pharmacother. 2024 Jul;176:116778. doi: 10.1016/j.biopha.2024.116778. Epub 2024 May 23. PMID: 38788601. 2: Yang Z, Wang Z, Deng X, Zhu L, Song Z, Cao C, Li X. P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis. Neural Regen Res. 2024 May;19(5):1078-1083. doi: 10.4103/1673-5374.380910. PMID: 37862211; PMCID: PMC10749631. 3: Wu Y, Hu Q, Wu X, Cai YN, Zhang YZ, Wu YX, Zhu G, Luo JN, Cheng HB, Yu JG, Wang XL, Gao L, Gao GD. P7C3-A20 Attenuates Microglial Inflammation and Brain Injury after ICH through Activating the NAD+/Sirt3 Pathway. Oxid Med Cell Longev. 2023 Feb 8;2023:7857760. doi: 10.1155/2023/7857760. PMID: 36819779; PMCID: PMC9936507. 4: Rahman MT, Bailey EM, Gansemer BM, Pieper AA, Manak JR, Green SH. Anti- inflammatory Therapy Protects Spiral Ganglion Neurons After Aminoglycoside Antibiotic-Induced Hair Cell Loss. Neurotherapeutics. 2023 Mar;20(2):578-601. doi: 10.1007/s13311-022-01336-2. Epub 2023 Jan 25. PMID: 36697994; PMCID: PMC10121993. 5: Wang SN, Wang Z, Wang XY, Zhang XP, Xu TY, Miao CY. Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents. Acta Pharmacol Sin. 2023 Mar;44(3):513-523. doi: 10.1038/s41401-022-00986-4. Epub 2022 Sep 13. PMID: 36100766; PMCID: PMC9958103. 6: Wang X, Wu J, Wang W, Zhang Y, He D, Xiao B, Zhang H, Song A, Xing Y, Li B. Reprogramming of Rat Fibroblasts into Induced Neurons by Small-Molecule Compounds In Vitro and In Vivo. ACS Chem Neurosci. 2022 Jul 20;13(14):2099-2109. doi: 10.1021/acschemneuro.2c00078. Epub 2022 Jun 20. PMID: 35723446. 7: Schroeder R, Nguyen L, Pieper AA, Stevens HE. Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress. Behav Brain Res. 2022 Jan 7;416:113558. doi: 10.1016/j.bbr.2021.113558. Epub 2021 Aug 25. PMID: 34453970; PMCID: PMC8573727. 8: Schroeder R, Sridharan P, Nguyen L, Loren A, Williams NS, Kettimuthu KP, Cintrón-Pérez CJ, Vázquez-Rosa E, Pieper AA, Stevens HE. Maternal P7C3-A20 Treatment Protects Offspring from Neuropsychiatric Sequelae of Prenatal Stress. Antioxid Redox Signal. 2021 Sep 1;35(7):511-530. doi: 10.1089/ars.2020.8227. Epub 2021 Jan 29. PMID: 33501899; PMCID: PMC8388250. 9: Yang Y, Fan Y, Zhang H, Zhang Q, Zhao Y, Xiao Z, Liu W, Chen B, Gao L, Sun Z, Xue X, Shu M, Dai J. Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury. Biomaterials. 2021 Feb;269:120479. doi: 10.1016/j.biomaterials.2020.120479. Epub 2020 Nov 15. PMID: 33223332. 10: Vázquez-Rosa E, Shin MK, Dhar M, Chaubey K, Cintrón-Pérez CJ, Tang X, Liao X, Miller E, Koh Y, Barker S, Franke K, Crosby DR, Schroeder R, Emery J, Yin TC, Fujioka H, Reynolds JD, Harper MM, Jain MK, Pieper AA. P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27667-27675. doi: 10.1073/pnas.2010430117. Epub 2020 Oct 21. PMID: 33087571; PMCID: PMC7959512. 11: Bai J, Zeng S, Zhu J, Fu C, He M, Zhu J, Chen S, Fu X, Li P, Lin Z. The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3β Signaling. Neuroscience. 2020 Aug 10;441:197-208. doi: 10.1016/j.neuroscience.2020.05.051. Epub 2020 Jun 3. PMID: 32504794. 12: Bavley CC, Kabir ZD, Walsh AP, Kosovsky M, Hackett J, Sun H, Vázquez-Rosa E, Cintrón-Pérez CJ, Miller E, Koh Y, Pieper AA, Rajadhyaksha AM. Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post- traumatic stress. Mol Psychiatry. 2021 Jun;26(6):2286-2298. doi: 10.1038/s41380-020-0730-8. Epub 2020 Apr 24. PMID: 32332995; PMCID: PMC8214244. 13: Hua X, Sun DY, Zhang WJ, Fu JT, Tong J, Sun SJ, Zeng FY, Ouyang SX, Zhang GY, Wang SN, Li DJ, Miao CY, Wang P. P7C3-A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP-activated protein kinase/CREB regulated transcription coactivator 2 pathway. Br J Pharmacol. 2021 May;178(10):2111-2130. doi: 10.1111/bph.15008. Epub 2020 Mar 24. PMID: 32037512. 14: Hill CS, Menon DK, Coleman MP. P7C3-A20 neuroprotection is independent of Wallerian degeneration in primary neuronal culture. Neuroreport. 2018 Dec 12;29(18):1544-1549. doi: 10.1097/WNR.0000000000001146. PMID: 30334859; PMCID: PMC6250284. 15: Bauman MD, Schumann CM, Carlson EL, Taylor SL, Vázquez-Rosa E, Cintrón-Pérez CJ, Shin MK, Williams NS, Pieper AA. Neuroprotective efficacy of P7C3 compounds in primate hippocampus. Transl Psychiatry. 2018 Sep 26;8(1):202. doi: 10.1038/s41398-018-0244-1. PMID: 30258178; PMCID: PMC6158178. 16: Zhang LQ, Nsumu M, Huang P, Heruth DP, Riordan SM, Shortt K, Zhang N, Grigoryev DN, Li DY, Friesen CA, Van Haandel L, Leeder JS, Olson J, Ye SQ. Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen- Induced Acute Liver Injury in Mice. Am J Pathol. 2018 Jul;188(7):1640-1652. doi: 10.1016/j.ajpath.2018.04.004. Epub 2018 Apr 22. PMID: 29684358; PMCID: PMC6024191. 17: LoCoco PM, Risinger AL, Smith HR, Chavera TS, Berg KA, Clarke WP. Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy. Elife. 2017 Nov 10;6:e29626. doi: 10.7554/eLife.29626. PMID: 29125463; PMCID: PMC5701795. 18: Oku H, Morishita S, Horie T, Kida T, Mimura M, Kojima S, Ikeda T. P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4877-4888. doi: 10.1167/iovs.17-22179. PMID: 28973334. 19: Loris ZB, Hynton JR, Pieper AA, Dietrich WD. Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats. Transl Stroke Res. 2018 Apr;9(2):146-156. doi: 10.1007/s12975-017-0565-z. Epub 2017 Aug 25. PMID: 28842830. 20: Loris ZB, Pieper AA, Dietrich WD. Corrigendum to "The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after stroke" [Exp. Neurol. 290 (2017) 63-73]. Exp Neurol. 2017 Dec;298(Pt A):134. doi: 10.1016/j.expneurol.2017.04.016. Epub 2017 May 13. Erratum for: Exp Neurol. 2017 Apr;290:63-73. doi: 10.1016/j.expneurol.2017.01.006. PMID: 28511786. 1: Iwatani Y, Hayashi H, Oba H, Oba M, Sawamura A, Moriyama Y, Takagi N. Possible involvement of NAMPT in neuronal survival in cerebral ischemic injury under high-glucose conditions through the FoxO3a/LC3 pathway. Biomed Pharmacother. 2024 Jul;176:116778. doi: 10.1016/j.biopha.2024.116778. Epub 2024 May 23. PMID: 38788601. 2: Yang Z, Wang Z, Deng X, Zhu L, Song Z, Cao C, Li X. P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis. Neural Regen Res. 2024 May;19(5):1078-1083. doi: 10.4103/1673-5374.380910. PMID: 37862211; PMCID: PMC10749631. 3: Wu Y, Hu Q, Wu X, Cai YN, Zhang YZ, Wu YX, Zhu G, Luo JN, Cheng HB, Yu JG, Wang XL, Gao L, Gao GD. P7C3-A20 Attenuates Microglial Inflammation and Brain Injury after ICH through Activating the NAD+/Sirt3 Pathway. Oxid Med Cell Longev. 2023 Feb 8;2023:7857760. doi: 10.1155/2023/7857760. PMID: 36819779; PMCID: PMC9936507. 4: Rahman MT, Bailey EM, Gansemer BM, Pieper AA, Manak JR, Green SH. Anti- inflammatory Therapy Protects Spiral Ganglion Neurons After Aminoglycoside Antibiotic-Induced Hair Cell Loss. Neurotherapeutics. 2023 Mar;20(2):578-601. doi: 10.1007/s13311-022-01336-2. Epub 2023 Jan 25. PMID: 36697994; PMCID: PMC10121993. 5: Wang SN, Wang Z, Wang XY, Zhang XP, Xu TY, Miao CY. Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents. Acta Pharmacol Sin. 2023 Mar;44(3):513-523. doi: 10.1038/s41401-022-00986-4. Epub 2022 Sep 13. PMID: 36100766; PMCID: PMC9958103. 6: Wang X, Wu J, Wang W, Zhang Y, He D, Xiao B, Zhang H, Song A, Xing Y, Li B. Reprogramming of Rat Fibroblasts into Induced Neurons by Small-Molecule Compounds In Vitro and In Vivo. ACS Chem Neurosci. 2022 Jul 20;13(14):2099-2109. doi: 10.1021/acschemneuro.2c00078. Epub 2022 Jun 20. PMID: 35723446. 7: Schroeder R, Nguyen L, Pieper AA, Stevens HE. Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress. Behav Brain Res. 2022 Jan 7;416:113558. doi: 10.1016/j.bbr.2021.113558. Epub 2021 Aug 25. PMID: 34453970; PMCID: PMC8573727. 8: Schroeder R, Sridharan P, Nguyen L, Loren A, Williams NS, Kettimuthu KP, Cintrón-Pérez CJ, Vázquez-Rosa E, Pieper AA, Stevens HE. Maternal P7C3-A20 Treatment Protects Offspring from Neuropsychiatric Sequelae of Prenatal Stress. Antioxid Redox Signal. 2021 Sep 1;35(7):511-530. doi: 10.1089/ars.2020.8227. Epub 2021 Jan 29. PMID: 33501899; PMCID: PMC8388250. 9: Yang Y, Fan Y, Zhang H, Zhang Q, Zhao Y, Xiao Z, Liu W, Chen B, Gao L, Sun Z, Xue X, Shu M, Dai J. Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury. Biomaterials. 2021 Feb;269:120479. doi: 10.1016/j.biomaterials.2020.120479. Epub 2020 Nov 15. PMID: 33223332. 10: Vázquez-Rosa E, Shin MK, Dhar M, Chaubey K, Cintrón-Pérez CJ, Tang X, Liao X, Miller E, Koh Y, Barker S, Franke K, Crosby DR, Schroeder R, Emery J, Yin TC, Fujioka H, Reynolds JD, Harper MM, Jain MK, Pieper AA. P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27667-27675. doi: 10.1073/pnas.2010430117. Epub 2020 Oct 21. PMID: 33087571; PMCID: PMC7959512. 11: Bai J, Zeng S, Zhu J, Fu C, He M, Zhu J, Chen S, Fu X, Li P, Lin Z. The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3β Signaling. Neuroscience. 2020 Aug 10;441:197-208. doi: 10.1016/j.neuroscience.2020.05.051. Epub 2020 Jun 3. PMID: 32504794. 12: Bavley CC, Kabir ZD, Walsh AP, Kosovsky M, Hackett J, Sun H, Vázquez-Rosa E, Cintrón-Pérez CJ, Miller E, Koh Y, Pieper AA, Rajadhyaksha AM. Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post- traumatic stress. Mol Psychiatry. 2021 Jun;26(6):2286-2298. doi: 10.1038/s41380-020-0730-8. Epub 2020 Apr 24. PMID: 32332995; PMCID: PMC8214244. 13: Hua X, Sun DY, Zhang WJ, Fu JT, Tong J, Sun SJ, Zeng FY, Ouyang SX, Zhang GY, Wang SN, Li DJ, Miao CY, Wang P. P7C3-A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP-activated protein kinase/CREB regulated transcription coactivator 2 pathway. Br J Pharmacol. 2021 May;178(10):2111-2130. doi: 10.1111/bph.15008. Epub 2020 Mar 24. PMID: 32037512. 14: Hill CS, Menon DK, Coleman MP. P7C3-A20 neuroprotection is independent of Wallerian degeneration in primary neuronal culture. Neuroreport. 2018 Dec 12;29(18):1544-1549. doi: 10.1097/WNR.0000000000001146. PMID: 30334859; PMCID: PMC6250284. 15: Bauman MD, Schumann CM, Carlson EL, Taylor SL, Vázquez-Rosa E, Cintrón-Pérez CJ, Shin MK, Williams NS, Pieper AA. Neuroprotective efficacy of P7C3 compounds in primate hippocampus. Transl Psychiatry. 2018 Sep 26;8(1):202. doi: 10.1038/s41398-018-0244-1. PMID: 30258178; PMCID: PMC6158178. 16: Zhang LQ, Nsumu M, Huang P, Heruth DP, Riordan SM, Shortt K, Zhang N, Grigoryev DN, Li DY, Friesen CA, Van Haandel L, Leeder JS, Olson J, Ye SQ. Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen- Induced Acute Liver Injury in Mice. Am J Pathol. 2018 Jul;188(7):1640-1652. doi: 10.1016/j.ajpath.2018.04.004. Epub 2018 Apr 22. PMID: 29684358; PMCID: PMC6024191. 17: LoCoco PM, Risinger AL, Smith HR, Chavera TS, Berg KA, Clarke WP. Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy. Elife. 2017 Nov 10;6:e29626. doi: 10.7554/eLife.29626. PMID: 29125463; PMCID: PMC5701795. 18: Oku H, Morishita S, Horie T, Kida T, Mimura M, Kojima S, Ikeda T. P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4877-4888. doi: 10.1167/iovs.17-22179. PMID: 28973334. 19: Loris ZB, Hynton JR, Pieper AA, Dietrich WD. Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats. Transl Stroke Res. 2018 Apr;9(2):146-156. doi: 10.1007/s12975-017-0565-z. Epub 2017 Aug 25. PMID: 28842830. 20: Loris ZB, Pieper AA, Dietrich WD. Corrigendum to "The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after stroke" [Exp. Neurol. 290 (2017) 63-73]. Exp Neurol. 2017 Dec;298(Pt A):134. doi: 10.1016/j.expneurol.2017.04.016. Epub 2017 May 13. Erratum for: Exp Neurol. 2017 Apr;290:63-73. doi: 10.1016/j.expneurol.2017.01.006. PMID: 28511786.