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MedKoo Cat#: 576903 | Name: Mabuterol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mabuterol hydrochloride is a selective β2 adrenoreceptor agonist. Mabuterol has a specific effect on beta 2-adrenoceptors with no beta 1-stimulation.

Chemical Structure

Mabuterol hydrochloride
Mabuterol hydrochloride
CAS#54240-36-7

Theoretical Analysis

MedKoo Cat#: 576903

Name: Mabuterol hydrochloride

CAS#: 54240-36-7

Chemical Formula: C13H19Cl2F3N2O

Exact Mass: 346.0827

Molecular Weight: 347.20

Elemental Analysis: C, 44.97; H, 5.52; Cl, 20.42; F, 16.42; N, 8.07; O, 4.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Broncholin; KF868; KF-868; KF 868; Mabuterol hydrochloride; Mabuterol HCl; PB 868; PB868; PB-868
IUPAC/Chemical Name
Benzenemethanol, 4-amino-3-chloro-alpha-(((1,1-dimethylethyl)amino)methyl)-5-(trifluoromethyl)-, monohydrochloride
InChi Key
MMCDXJOMPMIKGP-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H18ClF3N2O.ClH/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7;/h4-5,10,19-20H,6,18H2,1-3H3;1H
SMILES Code
[Cl-].CC(C)(C)[NH2+]CC(O)c1cc(Cl)c(N)c(c1)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Song X, Zhao C, Dai C, Ren Y, An N, Wen H, Pan LI, Cheng M, Zhang Y. Suppression of the increasing level of acetylcholine-stimulated intracellular Ca(2+) in guinea pig airway smooth muscle cells by mabuterol. Biomed Rep. 2015 Nov;3(6):778-786. Epub 2015 Aug 4. PubMed PMID: 26623015; PubMed Central PMCID: PMC4660599. 2: Lu X, Liu P, Chen H, Qin F, Li F. Enantioselective pharmacokinetics of mabuterol in rats studied using sequential achiral and chiral HPLC. Biomed Chromatogr. 2005 Nov;19(9):703-8. PubMed PMID: 16206140. 3: Amemiya K, Asano T, Arika T, Nakamura M, Kudoh M. Special toxicology--physical dependence potential, antigenicity and mutagenicity--of mabuterol. Arzneimittelforschung. 1984;34(11A):1685-6. PubMed PMID: 6152162. 4: Tu Y, Zhong J, Wang H, Pan J, Xu Z, Yang W, Luo Y. Synthesis of stable isotope labeled D(9) -Mabuterol, D(9) -Bambuterol, and D(9) -Cimbuterol. J Labelled Comp Radiopharm. 2016 Nov;59(13):546-551. doi: 10.1002/jlcr.3446. Epub 2016 Oct 13. PubMed PMID: 27739098. 5: Osada E, Sakaya S, Sanai K, Seri K. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. III: Effects on the central nervous system, striated muscle and carbohydrate and lipid metabolism. Arzneimittelforschung. 1984;34(11A):1652-8. PubMed PMID: 6152158. 6: Yamamoto I, Matsuura E, Horiba M, Akima K, Nomura K, Aizawa T. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76. PubMed PMID: 3900139. 7: Miyata T, Kai H, Furusawa K, Nakamura H, Saito M, Okano Y, Takahama K. Secretomotor and mucolytic effects of mabuterol, a novel bronchodilator. Arch Int Pharmacodyn Ther. 1987 Jul;288(1):147-60. PubMed PMID: 2889431. 8: Murai T, Maejima T, Sanai K, Osada E. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. I: Bronchodilating effect. Arzneimittelforschung. 1984;34(11A):1633-40. PubMed PMID: 6152156. 9: Guentert TW, Buskin JN, Galeazzi RL. Single dose pharmacokinetics of mabuterol in man. Arzneimittelforschung. 1984;34(11A):1691-6. PubMed PMID: 6152164. 10: Horiba M, Murai T, Nomura K, Yuge T, Sanai K, Osada E. Pharmacokinetic studies of mabuterol, a new selective beta 2-stimulant. II: Urinary metabolites of mabuterol in rats and their pharmacological effects. Arzneimittelforschung. 1984;34(11A):1668-79. PubMed PMID: 6152160. 11: Kawakami Y. First clinical studies on mabuterol. A summarizing report. Arzneimittelforschung. 1984;34(11A):1699-700. PubMed PMID: 6152166. 12: Amemiya K, Kudoh M, Suzuki H, Saga K, Hosaka K. Toxicology of mabuterol. Arzneimittelforschung. 1984;34(11A):1680-4. PubMed PMID: 6152161. 13: Ishizaki O, Daidohji S, Kimura K, Shibuya K, Horiguchi T, Sekiwa M. Reproduction studies with mabuterol in rats. Arzneimittelforschung. 1984;34(11A):1687-90. PubMed PMID: 6152163. 14: Osada E, Murai T, Ishizaka Y, Sanai K. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. II: Effects on the cardiovascular system and smooth muscle organs. Arzneimittelforschung. 1984;34(11A):1641-51. PubMed PMID: 6152157. 15: Qureshi GA, Eriksson A. Determination of clenbuterol and mabuterol in equine plasma by ion-pair liquid chromatography with electrochemical detection. Chromatographic and electrochemical characteristics. J Chromatogr. 1988 May 27;441(1):197-205. PubMed PMID: 2900250. 16: Akahane K, Furukawa Y, Ogiwara Y, Haniuda M, Chiba S. Beta-adrenoceptor blocking effects of a selective beta 2-agonist, mabuterol, on the isolated, blood-perfused right atrium of the dog. Br J Pharmacol. 1989 Jul;97(3):709-16. PubMed PMID: 2474351; PubMed Central PMCID: PMC1854580. 17: Nakamura M, Yamaya M, Fukushima T, Sekizawa K, Sasaki H, Takishima T. Effect of mabuterol on tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs. Respiration. 1991;58(1):33-6. PubMed PMID: 1677208. 18: Yuge T, Hase T, Takayanagi Y, Kamasuka T, Amemiya K, Horiba M. Pharmacokinetic studies of mabuterol, a new selective beta 2-stimulant. I: Studies on the absorption, distribution and excretion in rats. Arzneimittelforschung. 1984;34(11A):1659-67. PubMed PMID: 6152159. 19: Ulmer WT, Scholz HJ, Baines A. Pilot clinical trial with a new beta 2-sympathomimetic bronchodilator, mabuterol. Arzneimittelforschung. 1984;34(11A):1697-8. PubMed PMID: 6152165.

View History

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