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MedKoo Cat#: 414199 | Name: Povidone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Povidone is a polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. Povidone-iodine has been used as a medical antiseptic and disinfectant since 1952.

Chemical Structure

Povidone
Povidone
CAS#9003-39-8

Theoretical Analysis

MedKoo Cat#: 414199

Name: Povidone

CAS#: 9003-39-8

Chemical Formula: C6H13NOP2

Exact Mass: 177.0472

Molecular Weight: 177.12

Elemental Analysis: C, 40.69; H, 7.40; N, 7.91; O, 9.03; P, 34.97

Price and Availability

Size Price Availability Quantity
100mg USD 850.00 2 Weeks
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Related CAS #
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Synonym
Povidone; AT717; AT-717; AT 717; CCRIS3611; CCRIS-3611; CCRIS 3611;
IUPAC/Chemical Name
1-[1,2-bis(phosphanyl)ethyl]pyrrolidin-2-one
InChi Key
LQIAZOCLNBBZQK-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H13NOP2/c8-5-2-1-3-7(5)6(10)4-9/h6H,1-4,9-10H2
SMILES Code
O=C1N(C(P)CP)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Povidone is a polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.
In vitro activity:
This study aimed to explore the anti-inflammatory effects and underlying molecular mechanism of PVP-I (povidone-iodine) on lipopolysaccharide-stimulated airway epithelial cells and investigate whether nasal instillation of PVP-I can suppress mucosal inflammation in non-eosinophilic CRS mice. PVP-I blocked expressions of various inflammation-related molecules, such as NLRP3, NF-κB-p65, caspase-1, and IL-1β. Translocation of NF-κB to the nucleus, and assembly of NLRP3/ASC complexes in the nasal epithelial cells and non-eosinophilic CRS mice were also restricted. Reference: Sci Rep. 2022 Mar 7;12(1):3681. https://pubmed.ncbi.nlm.nih.gov/35256715/
In vivo activity:
Several formulations of Stress Coat® were investigated and the results showed that polyvinylpyrrolidone (PVP) (povidone), also known as povidone, an ingredient of Stress Coat®, when used alone, showed significantly higher slime production in goldfish than salt and Stress Coat® without PVP after 25 h. The results also showed that koi treated with compounds containing PVP showed better wound healing than those not exposed to PVP. Reference: PeerJ. 2017 Sep 6;5:e3759. https://pubmed.ncbi.nlm.nih.gov/28894641/
Solvent mg/mL mM comments
Solubility
DMSO 62.5 352.86
Ethanol 100.0 564.58
Water 75.0 423.43
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 177.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Gryson L, Meaume S, Feldkaemper I, Favalli F. Anti-biofilm Activity of Povidone-Iodine and Polyhexamethylene Biguanide: Evidence from In Vitro Tests. Curr Microbiol. 2023 Apr 1;80(5):161. doi: 10.1007/s00284-023-03257-5. PMID: 37004626; PMCID: PMC10067645. 2. Lee SH, Choi MR, Chung J, Choi SH, Park SK, Kim YM. Povidone iodine suppresses LPS-induced inflammation by inhibiting TLR4/MyD88 formation in airway epithelial cells. Sci Rep. 2022 Mar 7;12(1):3681. doi: 10.1038/s41598-022-07803-2. PMID: 35256715; PMCID: PMC8901750. 3. Hadipour Jahromy M, Najafi A, Majdi Nassab F, Moiniyan M. Effectiveness of Povidone-Iodine 1% Eye Drop on Streptococcus pneumoniae and Escherichia coli Induced-Keratitis in Mice. Galen Med J. 2019 Jun 2;8:e1161. doi: 10.22086/gmj.v8i0.1161. PMID: 34466468; PMCID: PMC8343812. 4. Shivappa RB, Christian LS, Law JM, Lewbart GA. Laboratory evaluation of different formulations of Stress Coat® for slime production in goldfish (Carassius auratus) and koi (Cyprinus carpio). PeerJ. 2017 Sep 6;5:e3759. doi: 10.7717/peerj.3759. PMID: 28894641; PMCID: PMC5591633.
In vitro protocol:
1. Gryson L, Meaume S, Feldkaemper I, Favalli F. Anti-biofilm Activity of Povidone-Iodine and Polyhexamethylene Biguanide: Evidence from In Vitro Tests. Curr Microbiol. 2023 Apr 1;80(5):161. doi: 10.1007/s00284-023-03257-5. PMID: 37004626; PMCID: PMC10067645. 2. Lee SH, Choi MR, Chung J, Choi SH, Park SK, Kim YM. Povidone iodine suppresses LPS-induced inflammation by inhibiting TLR4/MyD88 formation in airway epithelial cells. Sci Rep. 2022 Mar 7;12(1):3681. doi: 10.1038/s41598-022-07803-2. PMID: 35256715; PMCID: PMC8901750.
In vivo protocol:
1. Hadipour Jahromy M, Najafi A, Majdi Nassab F, Moiniyan M. Effectiveness of Povidone-Iodine 1% Eye Drop on Streptococcus pneumoniae and Escherichia coli Induced-Keratitis in Mice. Galen Med J. 2019 Jun 2;8:e1161. doi: 10.22086/gmj.v8i0.1161. PMID: 34466468; PMCID: PMC8343812. 2. Shivappa RB, Christian LS, Law JM, Lewbart GA. Laboratory evaluation of different formulations of Stress Coat® for slime production in goldfish (Carassius auratus) and koi (Cyprinus carpio). PeerJ. 2017 Sep 6;5:e3759. doi: 10.7717/peerj.3759. PMID: 28894641; PMCID: PMC5591633.
1: Sahay P, Maharana PK. Increasing Povidone-Iodine Exposure in Endothelial Keratoplasty Tissue Processing and Fungal Infection Impact. Cornea. 2019 Nov;38(11):e50. doi: 10.1097/ICO.0000000000002139. PMID: 31478949. 2: Trautinger F. Controversy on the Use of Povidone-Iodine in Chronic Wounds. Skin Pharmacol Physiol. 2018;31(5):261. doi: 10.1159/000491641. Epub 2018 Aug 8. PMID: 30089302. 3: Luan S, Wang C. Hyaluronic Acid-Povidone-Iodine Compound Facilitates Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Rodent Model. Plast Reconstr Surg. 2020 Feb;145(2):454e-455e. doi: 10.1097/PRS.0000000000006449. PMID: 31985683. 4: Oberg MS. Povidone-iodine solutions in traumatic wound preparation. Am J Emerg Med. 1987 Nov;5(6):553-5. doi: 10.1016/0735-6757(87)90199-9. PMID: 3311063. 5: Chen RF, Wang CT, Kuo YR. Reply: Hyaluronic Acid-Povidone-Iodine Compound Facilitates Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Rodent Model. Plast Reconstr Surg. 2020 Feb;145(2):455e-456e. doi: 10.1097/PRS.0000000000006450. PMID: 31985684. 6: Davis GH, Finlayson N, Kemp R. Dilution of povidone-iodine. Med J Aust. 1985 Sep 30;143(7):321. doi: 10.5694/j.1326-5377.1985.tb123038.x. PMID: 4046931. 7: Zamora JL. Chemical and microbiologic characteristics and toxicity of povidone-iodine solutions. Am J Surg. 1986 Mar;151(3):400-6. doi: 10.1016/0002-9610(86)90477-0. PMID: 3513654. 8: Kiffney GT Jr, Hattaway AC. Povidone-iodine as an ophthalmic antiseptic. Surg Forum. 1966;17:434-6. PMID: 5920995. 9: Naunton Morgan TC, Firmin R, Mason B, Monks V, Caro D. Prophylactic povidone iodine in minor wounds. Injury. 1980 Sep;12(2):104-6. doi: 10.1016/0020-1383(80)90132-1. PMID: 7009430. 10: Brard M, Michel P. Bétadine [Betadine]. Soins. 1986 Feb;(471):I-II. French. PMID: 3635248. 11: Ramaswamykanive H, Nanavati Z, Mackie J, Linderman R, Lavee O. Cardiovascular collapse following povidone-iodine wash. Anaesth Intensive Care. 2011 Jan;39(1):127-30. doi: 10.1177/0310057X1103900121. PMID: 21375103.