MedKoo Cat#: 525897 | Name: MEK Inhibitor I

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MEK Inhibitor I is a selective and potent inhibitor of MEK.

Chemical Structure

MEK Inhibitor I
MEK Inhibitor I
CAS#297744-42-4

Theoretical Analysis

MedKoo Cat#: 525897

Name: MEK Inhibitor I

CAS#: 297744-42-4

Chemical Formula: C21H18N4OS

Exact Mass: 374.1201

Molecular Weight: 374.46

Elemental Analysis: C, 67.36; H, 4.85; N, 14.96; O, 4.27; S, 8.56

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Synonym
MEK Inhibitor I; MEK-IN-4; NEN44424; NEN-44424; NEN 44424;
IUPAC/Chemical Name
3-Amino-3-(2-amino-phenylsulfanyl)-2-[3-(hydroxy-pyridin-4-yl-methyl)-phenyl]-acrylonitrile
InChi Key
NHBMKTBZZSJUGA-FXBPSFAMSA-N
InChi Code
InChI=1S/C21H18N4OS/c22-13-17(21(24)27-19-7-2-1-6-18(19)23)15-4-3-5-16(12-15)20(26)14-8-10-25-11-9-14/h1-12,20,26H,23-24H2/b21-17-
SMILES Code
N#C/C(C1=CC=CC(C(O)C2=CC=NC=C2)=C1)=C(N)/SC3=CC=CC=C3N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 374.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Johnson D. Is there a role for single-agent MEK inhibition in melanoma? Clin Adv Hematol Oncol. 2016 Dec;14(12):976-978. PubMed PMID: 28212360. 2: Thomas CL, Mortimer PS, Larkin JM, Basu TN, Gore ME, Fearfield L. A mitogen-activated protein kinase kinase inhibitor induced compound skin toxicity with oedema in metastatic malignant melanoma. Clin Exp Dermatol. 2016 Apr;41(3):267-71. doi: 10.1111/ced.12722. Epub 2015 Sep 28. PubMed PMID: 26411345. 3: Crassini K, Stevenson WS, Mulligan SP, Best OG. The MEK1/2 inhibitor, MEKi-1, induces cell death in chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment and is synergistic with fludarabine. Leuk Lymphoma. 2015;56(12):3407-17. doi: 10.3109/10428194.2015.1032963. Epub 2015 Aug 26. PubMed PMID: 25804768. 4: Shen B, Kwan HY, Ma X, Wong CO, Du J, Huang Y, Yao X. cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. J Biol Chem. 2011 Jun 3;286(22):19439-45. doi: 10.1074/jbc.M110.210294. Epub 2011 Apr 12. PubMed PMID: 21487005; PubMed Central PMCID: PMC3103323.