MedKoo Cat#: 464734 | Name: LFN00811

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LFN00811 is a novel anti-HIV active "dimeric" prodrug of 2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine monophosphate (d4TMP). This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

LFN00811
LFN00811
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464734

Name: LFN00811

CAS#: unknown

Chemical Formula: C36H36N4O14P2

Exact Mass: 810.1703

Molecular Weight: 810.65

Elemental Analysis: C, 53.34; H, 4.48; N, 6.91; O, 27.63; P, 7.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
LFN00811; LFN 00811; LFN-00811; Bis-5-methyl-cycloSal-d4TMP; bis-5-Me-cycloSal-d4TMP;
IUPAC/Chemical Name
1-((2R,5S)-5-(((6,6'-dimethyl-2'-(((2R,5S)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methoxy)-2,2'-dioxido-4H,4'H-[8,8'-bibenzo[d][1,3,2]dioxaphosphinin]-2-yl)oxy)methyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
InChi Key
LCENIOIBBAMNNL-FIQHEDESSA-N
InChi Code
InChI=1S/C36H36N4O14P2/c1-19-9-23-15-47-55(45,49-17-25-5-7-29(51-25)39-13-21(3)33(41)37-35(39)43)53-31(23)27(11-19)28-12-20(2)10-24-16-48-56(46,54-32(24)28)50-18-26-6-8-30(52-26)40-14-22(4)34(42)38-36(40)44/h5-14,25-26,29-30H,15-18H2,1-4H3,(H,37,41,43)(H,38,42,44)/t25-,26+,29+,30-,55?,56?
SMILES Code
O=C1NC(C(C)=CN1[C@@H]2O[C@H](COP3(OCC4=CC(C)=CC(C5=C6OP(OCC6=CC(C)=C5)(OC[C@@H]7O[C@H](N(C(N8)=O)C=C(C)C8=O)C=C7)=O)=C4O3)=O)C=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 810.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ducho C, Görbig U, Jessel S, Gisch N, Balzarini J, Meier C. Bis- cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides. J Med Chem. 2007 Mar 22;50(6):1335-46. doi: 10.1021/jm0611713. Epub 2007 Mar 1. PMID: 17328534.