MedKoo Cat#: 414197 | Name: Piperoxan Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piperoxan Free Base is a benzodioxane alpha-adrenergic blocking agent with considerable stimulatory action. It has been used to diagnose PHEOCHROMOCYTOMA and as an antihypertensive agent.

Chemical Structure

Piperoxan Free Base
Piperoxan Free Base
CAS# 59-39-2 (free base)

Theoretical Analysis

MedKoo Cat#: 414197

Name: Piperoxan Free Base

CAS#: 59-39-2 (free base)

Chemical Formula: C14H19NO2

Exact Mass: 233.1416

Molecular Weight: 233.31

Elemental Analysis: C, 72.07; H, 8.21; N, 6.00; O, 13.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Piperoxan Free Base; F 933; F-933; F933; Benodaine
IUPAC/Chemical Name
1,4-Benzodioxan, 2-(piperidinomethyl)-
InChi Key
LYKMMUBOEFYJQG-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H19NO2/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12/h2-3,6-7,12H,1,4-5,8-11H2
SMILES Code
C1(CN2CCCCC2)OC3=CC=CC=C3OC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 233.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Blakeley AG, Summers RJ. The effects of piperoxan on uptake of noradrenaline and overflow of transmitter in the isolated blood perfused spleen of the cat. Br J Pharmacol. 1978 Aug;63(4):683-7. doi: 10.1111/j.1476-5381.1978.tb17283.x. PMID: 28808; PMCID: PMC1668122. 2: EMLET JR, GRIMSON KS, BELL DM, ORGAIN ES. Use of piperoxan and regitine as routine tests in patients with hypertension. J Am Med Assoc. 1951 Aug 11;146(15):1383-6. doi: 10.1001/jama.1951.03670150017006. PMID: 14850300. 3: Mouillé P, Dabiré H, Fournier B, Schmitt H. Etude comparative du pipeéroxane et de l'(imidazolinyl-2)-2-benzodioxane 1-4 (170 150) sur les récepteurs pré- et postsynaptiques du rat [Comparative study of piperoxan and 2-(2-imidazolinyl)-1, 4-benzodioxane (170 150) on pre- and postsynaptic receptors in the rat]. J Pharmacol. 1982 Jul-Sep;13(3):389-97. French. PMID: 6290793. 4: PLACE VA. Piperoxan hydrochloride (benzodioxan) test; report of a false positive reaction. J Am Med Assoc. 1951 Jul 28;146(13):1227-9. doi: 10.1001/jama.1951.63670130007012c. PMID: 14850260. 5: NEW and nonofficial remedies: piperoxan hydrochloride. J Am Med Assoc. 1951 Apr 14;145(15):1135. PMID: 14813906. 6: PELNER L. Treatment of local ischemia due to levarterenol (levophed) leakage with piperoxan. J Am Med Assoc. 1957 Oct 5;165(5):444-7. doi: 10.1001/jama.1957.02980230014004. PMID: 13462810. 7: La Marca S, Dunn RW. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54(10):PL179-84. doi: 10.1016/0024-3205(94)00556-7. PMID: 7906377. 8: Borthwick AD. Fluparoxan: A Comprehensive Review of its Discovery, Adrenergic and CNS Activity and Treatment of Cognitive Dysfunction in Central Neurodegenerative Diseases. Mini Rev Med Chem. 2017;17(7):572-582. doi: 10.2174/1389557516666160321115041. PMID: 26996616. 9: Laubie M, Schmitt H. Brainstem mechanisms in the modulation of the sympathetic baroreflex by piperoxan. Eur J Pharmacol. 1988 Mar 29;148(2):143-51. doi: 10.1016/0014-2999(88)90558-4. PMID: 3378569. 10: FREEDMAN BJ. Accidental adrenaline overdosage and its treatment with piperoxan. Lancet. 1955 Sep 17;269(6890):575-8. doi: 10.1016/s0140-6736(55)92581-2. PMID: 13252923.