Synonym
Phenprobamate; MH532; MH 532; MH-532
IUPAC/Chemical Name
1-Propanol, 3-phenyl-, carbamate
InChi Key
CAMYKONBWHRPDD-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H13NO2/c11-10(12)13-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H2,11,12)
SMILES Code
NC(OCCCC1=CC=CC=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Phenprobamate is a centrally acting skeletal muscle relaxant.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
179.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Demir B, Demir Y, Aksoy I, Kilic OH, Gucyetmez V, Savas HA. Phenprobamate dependence: a case report. Addict Behav. 2015 Jun;45:232-3. doi: 10.1016/j.addbeh.2015.01.037. Epub 2015 Feb 13. PMID: 25727392.
2: Duzenli T, Tanoglu A, Akyol T, Kara M, Yazgan Y. Drug-induced Liver Injury Caused by Phenprobamate: Strong Probability Due to Repeated Toxicity. Euroasian J Hepatogastroenterol. 2019 Jan-Jun;9(1):49-51. doi: 10.5005/jp- journals-10018-1295. PMID: 31988867; PMCID: PMC6969320.
3: Sun JX, Embil K, Lee CS. Time-dependent absorption of phenprobamate following multiple dosing in rats. Pharm Res. 1988 Jun;5(6):387-90. doi: 10.1023/a:1015967829826. PMID: 3244651.
4: Emet M, Aslan S, Cakir ZG, Uyanik A, Uzkeser M, Hacimuftuoglu A, Emre H. Plasmapheresis is useful in phenprobamate overdose. Am J Emerg Med. 2009 Jun;27(5):626.e1-2. doi: 10.1016/j.ajem.2008.08.022. PMID: 19497474.
5: Tulunay FC, Onaran HO, Ergün H, Ucar A, Usanmaz S, Embil K, Tulunay M. Pharmacokinetics of phenprobamate after oral administration to healthy subjects. Arzneimittelforschung. 1998 Nov;48(11):1068-71. PMID: 9850426.
6: Sun JX, Embil K, Chow DS, Lee CC. High-performance liquid chromatographic analysis, plasma protein binding and red blood cell partitioning of phenprobamate. Biopharm Drug Dispos. 1987 Jul-Aug;8(4):341-51. doi: 10.1002/bdd.2510080405. PMID: 3620593.
7: Altun ML, Erk N. The rapid quantitative analysis of phenprobamate and acetaminophen by RP-LC and compensation technique. J Pharm Biomed Anal. 2001 Apr;25(1):85-92. doi: 10.1016/s0731-7085(00)00490-8. PMID: 11274861.
8: Farrier DS. The occurrence of 3-hydroxy-phenprobamate, a new metabolite of phenprobamate, in dogs and humans. Arzneimittelforschung. 1975 May;25(5):813-7. PMID: 1242331.
9: Tasdemir HA, Yildiran A, Islek I, Sancak R, Dilber C. Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients. Nephrol Dial Transplant. 2002 May;17(5):941. doi: 10.1093/ndt/17.5.941. PMID: 11981094.
10: Schatz F, Jahn U. Untersuchungen über Resorption und Metabolismus von gamma- Phenylpropylcarbamat (Phenprobamat) [Studies on the resorption and metabolism of gamma-phenylpropyl carbamate (Phenprobamate)]. Arzneimittelforschung. 1966 Jul;16(7):866-70. German. PMID: 6014716.
