Synonym
Trimethidinium methosulfate; HA106; HA-106; HA 106; Wy1395; Wy-1395; Wy 1395
IUPAC/Chemical Name
1,3,8,8-Tetramethyl-3-(3-(trimethylammonio)propyl)-3-azoniabicyclo(3.2.1)octane bis(methyl sulfate)
InChi Key
ZOSQTCOGKFRDET-UHFFFAOYSA-L
InChi Code
InChI=1S/C17H36N2.2CH4O4S/c1-16(2)15-9-10-17(16,3)14-19(7,13-15)12-8-11-18(4,5)6;2*1-5-6(2,3)4/h15H,8-14H2,1-7H3;2*1H3,(H,2,3,4)/q+2;;/p-2
SMILES Code
C[N+](CCC[N+]1(C)CC(C2(C)C)(C)CCC2C1)(C)C.O=S(OC)([O-])=O.O=S(OC)([O-])=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
490.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: PELNER L, WALDMAN S. Trimethidinium methosulfate in the treatment of moderate and severe hypertension. J Am Geriatr Soc. 1960 Mar;8:168-76. doi: 10.1111/j.1532-5415.1960.tb00396.x. PMID: 13856236.
2: MOURY NF, KINLAW WB, DONAGHUE AH. A controlled clinical comparison of guanethidine and trimethidinium methosulfate. J Germantown Hosp. 1962 Feb;3:6-11. PMID: 14476712.
3: PERKINS HT Jr, BOGDONOFF MD, BLACK MC. The treatment of hypertension with trimethidinium methosulfate in an outpatient clinic group. South Med J. 1960 Feb;53:224-9. doi: 10.1097/00007611-196002000-00017. PMID: 14431862.
4: GIFFORD RW Jr. Treatment of hypertension with trimethidinium methosulfate, a new ganglion-blocking drug. Proc Staff Meet Mayo Clin. 1959 Sep 30;34:481-8. PMID: 13849949.
5: BORHANI NO. Use of trimethidinium methosulfate (a new ganglionic blocking agent) in the treatment of hypertension. Ann Intern Med. 1959 Nov;51:983-92. doi: 10.7326/0003-4819-51-5-983. PMID: 13802828.
6: AFONSO S, ROWE GG, CHELIUS CJ, GURTNER HP, LOPEZ JE, CRUMPTON CW. Acute systemic and coronary hemodynamic effects of trimethidinium methosulfate. Proc Soc Exp Biol Med. 1962 May;110:74-7. doi: 10.3181/00379727-110-27428. PMID: 13859541.
7: DUNSMORE RA, DUNSMORE LD, GOLDMAN A, ELIAS M, WARNER RS. Treatment of ambulatory hypertensive patients with trimethidinium methosulfate. Am J Med Sci. 1958 Oct;236(4):483-6. PMID: 13582943.
8: SMIRK FH. Ganglionic blockade by trimethidinium methosulphate. Am Heart J. 1959 Nov;58:701-5. doi: 10.1016/0002-8703(59)90227-3. PMID: 13831827.
9: FRITZER W, WATSCHINGER B. [On hypertension therapy with camphidonium compositum]. Wien Z Inn Med. 1959 Sep;40:335-44. German. PMID: 13825295.
10: LUBECK I, MERBITZ H, SCHENNETTEN F. Erfahrungen mit dem Camphidonium-Test, zugleich ein Beitrag zur Frage der Einwirkung der Ganglienblockade auf den Cholesterinspiegel [Results with the camphidonium test as well as an observation on the effect of the ganglion block on cholesterol levels]. Z Gesamte Inn Med. 1958 Jun 1;13(11):380-4. German. PMID: 13581865.
